Stem Cell Technology for Tendon Regeneration: Current Status, Challenges, and Future Research Directions

Overview

Journal Stem Cells Cloning

Publisher Dove Medical Press

Specialty Biotechnology

Date 2015 Dec 31

PMID 26715856

Citations 48

Authors

Pauline Po Yee Lui

Affiliations

Soon will be listed here.

Abstract

Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges of tendon repair by reviewing the anatomy of tendon. Next, I discussed the advantages and limitations of using different types of stem cells compared to terminally differentiated cells for tendon tissue engineering. The safety and efficacy of application of stem cells and their modified counterparts for tendon tissue engineering were then summarized after a systematic literature search in PubMed. The challenges and future research directions to enhance, optimize, and standardize stem cell-based therapies for augmenting tendon repair were then discussed.

Citing Articles

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling.

Chen J, Sheng R, Mo Q, Backman L, Lu Z, Long Q Bioact Mater. 2024; 44:319-338.

PMID: 39512422 PMC: 11541688. DOI: 10.1016/j.bioactmat.2024.10.016.

Endoscopic Application of a Collagen Scaffold for Treatment of Achilles Tendinopathy.

Ling S, Yung P Arthrosc Tech. 2024; 13(10):103071.

PMID: 39479042 PMC: 11519970. DOI: 10.1016/j.eats.2024.103071.

Transcriptome-Optimized Hydrogel Design of a Stem Cell Niche for Enhanced Tendon Regeneration.

Zhang W, Rao Y, Wong S, Wu Y, Zhang Y, Yang R Adv Mater. 2024; 37(2):e2313722.

PMID: 39417770 PMC: 11733723. DOI: 10.1002/adma.202313722.

Fibrin Scaffolds Perfused with Transforming Growth Factor-β1 as an In Vitro Model to Study Healthy and Tendinopathic Human Tendon Stem/Progenitor Cells.

Ciardulli M, Lovecchio J, Parolini O, Giordano E, Maffulli N, Della Porta G Int J Mol Sci. 2024; 25(17).

PMID: 39273510 PMC: 11395617. DOI: 10.3390/ijms25179563.

Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites.

Kent 3rd R, Huang A, Baker B Adv Healthc Mater. 2024; 13(29):e2400668.

PMID: 39135411 PMC: 11582515. DOI: 10.1002/adhm.202400668.

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