The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jun 12

PMID 26064975

Citations 34

Authors

Jie Chen

Chonghui Li

Liangan Chen

Affiliations

Soon will be listed here.

Abstract

Microvesicles (MVs) are membrane vesicles that are released by many types of cells and have recently been considered important mediators of cell-to-cell communication. MVs serve as a vehicle to transfer proteins and messenger RNA and microRNA (miRNA) to distant cells, which alters the gene expression, proliferation, and differentiation of the recipient cells. Several studies have demonstrated that mesenchymal stem cells (MSCs) have the capacity to reverse acute and chronic lung injury in different experimental models through paracrine mechanisms. This paracrine action may be partially accounted for by MVs that are derived from MSCs. MSC-derived MVs may confer a stem cell-like phenotype to injured cells with the consequent activation of self-regenerative programmers. In this review, we summarize the characteristics and biological activities of MSC-derived MVs, and we describe their potential in novel therapeutic approaches in regenerative medicine to repair damaged tissues. Additionally, we provide an overview of studies that have assessed the role of MSC-derived MVs in lung diseases, including the mechanisms that may account for their therapeutic potential. Finally, we discuss the clinical use of MSC-derived MVs with several suggestions for enhancing their therapeutic efficiency.

Citing Articles

Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells.

Saad-Naguib M, Kenfack Y, Sherman L, Chafitz O, Morelli S Front Endocrinol (Lausanne). 2024; 14:1268990.

PMID: 38344687 PMC: 10854221. DOI: 10.3389/fendo.2023.1268990.

Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency.

Martirosyan Y, Silachev D, Nazarenko T, Birukova A, Vishnyakova P, Sukhikh G Life (Basel). 2023; 13(12).

PMID: 38137848 PMC: 10744991. DOI: 10.3390/life13122247.

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments.

Ghasemzadeh-Hasankolaei M, Pinto C, Jesus D, Saraiva J, Mano J Mater Today Bio. 2023; 23:100861.

PMID: 38058695 PMC: 10696388. DOI: 10.1016/j.mtbio.2023.100861.

The Role of Mesenchymal Stem Cell Secretome (Extracellular Microvesicles and Exosomes) in Animals' Musculoskeletal and Neurologic-Related Disorders.

Carrera A, Minto B, Malard P, Brunel H Vet Med Int. 2023; 2023:8819506.

PMID: 38023428 PMC: 10645499. DOI: 10.1155/2023/8819506.

Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.

Zaripova L, Midgley A, Christmas S, Beresford M, Pain C, Baildam E Int J Mol Sci. 2023; 24(22).

PMID: 38003230 PMC: 10671211. DOI: 10.3390/ijms242216040.

References

FRIEDENSTEIN A, PETRAKOVA K, Kurolesova A, Frolova G . Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968; 6(2):230-47. View

Lee J, Fang X, Krasnodembskaya A, Howard J, Matthay M . Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells. 2011; 29(6):913-9. PMC: 3293251. DOI: 10.1002/stem.643. View

Collino F, Deregibus M, Bruno S, Sterpone L, Aghemo G, Viltono L . Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010; 5(7):e11803. PMC: 2910725. DOI: 10.1371/journal.pone.0011803. View

Chan J, Tang K, Patel A, Bonilla L, Pierobon N, Ponzio N . Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood. 2006; 107(12):4817-24. PMC: 1895812. DOI: 10.1182/blood-2006-01-0057. View

Qin Z, Xu J, Qu J, Zhang J, Sai Y, Chen C . Intrapleural delivery of MSCs attenuates acute lung injury by paracrine/endocrine mechanism. J Cell Mol Med. 2012; 16(11):2745-53. PMC: 4118243. DOI: 10.1111/j.1582-4934.2012.01597.x. View

Ionescu L, Byrne R, van Haaften T, Vadivel A, Alphonse R, Rey-Parra G . Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol. 2012; 303(11):L967-77. PMC: 3532523. DOI: 10.1152/ajplung.00144.2011. View

Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T . The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011; 29(4):725-35. PMC: 3322548. DOI: 10.1002/stem.604. View

Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee J . Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010; 28(12):2229-38. PMC: 3293245. DOI: 10.1002/stem.544. View

Sarkar A, Mitra S, Mehta S, Raices R, Wewers M . Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One. 2009; 4(9):e7140. PMC: 2744928. DOI: 10.1371/journal.pone.0007140. View

10.

Mause S, Weber C . Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res. 2010; 107(9):1047-57. DOI: 10.1161/CIRCRESAHA.110.226456. View

11.

Xin H, Li Y, Liu Z, Wang X, Shang X, Cui Y . MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells. 2013; 31(12):2737-46. PMC: 3788061. DOI: 10.1002/stem.1409. View

12.

Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, Dvorak P . Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 2006; 20(5):847-56. DOI: 10.1038/sj.leu.2404132. View

13.

Chen J, Li C, Gao X, Li C, Liang Z, Yu L . Keratinocyte growth factor gene delivery via mesenchymal stem cells protects against lipopolysaccharide-induced acute lung injury in mice. PLoS One. 2013; 8(12):e83303. PMC: 3867420. DOI: 10.1371/journal.pone.0083303. View

14.

Stagg J, Pommey S, Eliopoulos N, Galipeau J . Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood. 2005; 107(6):2570-7. DOI: 10.1182/blood-2005-07-2793. View

15.

Gyorgy B, Szabo T, Pasztoi M, Pal Z, Misjak P, Aradi B . Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011; 68(16):2667-88. PMC: 3142546. DOI: 10.1007/s00018-011-0689-3. View

16.

Wang H, Yang Y, Zhao L, Xiao F, Zhang Q, Wen M . Hepatocyte growth factor gene-modified mesenchymal stem cells reduce radiation-induced lung injury. Hum Gene Ther. 2013; 24(3):343-53. DOI: 10.1089/hum.2012.177. View

17.

Taraboletti G, DAscenzo S, Giusti I, Marchetti D, Borsotti P, Millimaggi D . Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH. Neoplasia. 2006; 8(2):96-103. PMC: 1578512. DOI: 10.1593/neo.05583. View

18.

Camussi G, Deregibus M, Cantaluppi V . Role of stem-cell-derived microvesicles in the paracrine action of stem cells. Biochem Soc Trans. 2013; 41(1):283-7. DOI: 10.1042/BST20120192. View

19.

Janowska-Wieczorek A, Majka M, Kijowski J, Baj-Krzyworzeka M, Reca R, Turner A . Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood. 2001; 98(10):3143-9. DOI: 10.1182/blood.v98.10.3143. View

20.

Lee C, Mitsialis S, Aslam M, Vitali S, Vergadi E, Konstantinou G . Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012; 126(22):2601-11. PMC: 3979353. DOI: 10.1161/CIRCULATIONAHA.112.114173. View