Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2024 Aug 13

PMID 39135411

Authors

Robert N Kent 3rd

Alice H Huang

Brendon M Baker

Affiliations

Soon will be listed here.

Abstract

This review highlights the promise of fiber-reinforced hydrogel composites (FRHCs) for augmenting tendon and ligament repair and regeneration. Composed of reinforcing fibers embedded in a hydrogel, these scaffolds provide both mechanical strength and a conducive microenvironment for biological processes required for connective tissue regeneration. Typical properties of FRHCs are discussed, highlighting their ability to simultaneously fulfill essential mechanical and biological design criteria for a regenerative scaffold. Furthermore, features of FRHCs are described that improve specific biological aspects of tendon healing including mesenchymal progenitor cell recruitment, early polarization to a pro-regenerative immune response, tenogenic differentiation of recruited progenitor cells, and subsequent production of a mature, aligned collagenous matrix. Finally, the review offers a perspective on clinical translation of tendon FRHCs and outlines key directions for future work.

Citing Articles

Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites.

Kent 3rd R, Huang A, Baker B Adv Healthc Mater. 2024; 13(29):e2400668.

PMID: 39135411 PMC: 11582515. DOI: 10.1002/adhm.202400668.

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