Enhancing Adoptive T Cell Immunotherapy with MicroRNA Therapeutics

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2015 Dec 30

PMID 26710685

Citations 22

Authors

Yun Ji

James D Hocker

Luca Gattinoni

Affiliations

Soon will be listed here.

Abstract

Adoptive T cell-based immunotherapies can mediate complete and durable regressions in patients with advanced cancer, but current response rates remain inadequate. Maneuvers to improve the fitness and antitumor efficacy of transferred T cells have been under extensive exploration in the field. Small non-coding microRNAs have emerged as critical modulators of immune system homeostasis and T cell immunity. Here, we summarize recent advances in our understanding of the role of microRNAs in regulating T cell activation, differentiation, and function. We also discuss how microRNA therapeutics could be employed to fine-tune T cell receptor signaling and enhance T cell persistence and effector functions, paving the way for the next generation of adoptive immunotherapies.

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