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Long Noncoding RNA Regulation of Pluripotency

Overview
Journal Stem Cells Int
Publisher Wiley
Specialty Cell Biology
Date 2015 Dec 24
PMID 26697072
Citations 37
Authors
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Abstract

Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs.

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References
1.
Ulitsky I, Bartel D . lincRNAs: genomics, evolution, and mechanisms. Cell. 2013; 154(1):26-46. PMC: 3924787. DOI: 10.1016/j.cell.2013.06.020. View

2.
Rosa A, Spagnoli F, Brivanlou A . The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection. Dev Cell. 2009; 16(4):517-27. DOI: 10.1016/j.devcel.2009.02.007. View

3.
Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M . Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease. J Mol Cell Cardiol. 2014; 76:55-70. PMC: 4445080. DOI: 10.1016/j.yjmcc.2014.08.009. View

4.
Bertani S, Sauer S, Bolotin E, Sauer F . The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin. Mol Cell. 2011; 43(6):1040-6. PMC: 3176448. DOI: 10.1016/j.molcel.2011.08.019. View

5.
Rosa A, Brivanlou A . Regulatory non-coding RNAs in pluripotent stem cells. Int J Mol Sci. 2013; 14(7):14346-73. PMC: 3742248. DOI: 10.3390/ijms140714346. View