The Essentiality of Non-coding RNAs in Cell Reprogramming

Overview

Journal Noncoding RNA Res

Date 2018 Aug 31

PMID 30159423

Citations 11

Authors

Joachim Luginbuhl

Divya Mundackal Sivaraman

Jay W Shin

Affiliations

Soon will be listed here.

Abstract

In mammals, short (mi-) and long non-coding (lnc) RNAs are immensely abundant and they are proving to be more functional than ever before. Particularly in cell reprogramming, non-coding RNAs are essential to establish the pluripotent network and are indispensable to reprogram somatic cells to pluripotency. Through systematic screening and mechanistic studies, diverse functional features of both miRNA and lncRNAs have emerged as either scaffolds, inhibitors, or co-activators, necessary to orchestrate the intricacy of gene regulation. Furthermore, the collective characterizations of both miRNA and lncRNA reveal their interdependency (e.g. sequestering the function of the other) to modulate cell reprogramming. This review broadly explores the regulatory processes of cell reprogramming - with key functional examples in neuronal and cardiac differentiations - in the context of both short and long non-coding RNAs.

Citing Articles

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