Mechanisms and Functional Significance of Stroke-Induced Neurogenesis

Overview

Journal Front Neurosci

Date 2015 Dec 24

PMID 26696816

Citations 37

Authors

Quentin Marlier

Sebastien Verteneuil

Renaud Vandenbosch

Brigitte Malgrange

Affiliations

Soon will be listed here.

Abstract

Stroke affects one in every six people worldwide, and is the leading cause of adult disability. After stroke, some limited spontaneous recovery occurs, the mechanisms of which remain largely unknown. Multiple, parallel approaches are being investigated to develop neuroprotective, reparative and regenerative strategies for the treatment of stroke. For years, clinical studies have tried to use exogenous cell therapy as a means of brain repair, with varying success. Since the rediscovery of adult neurogenesis and the identification of adult neural stem cells in the late nineties, one promising field of investigation is focused upon triggering and stimulating this self-repair system to replace the neurons lost following brain injury. For instance, it is has been demonstrated that the adult brain has the capacity to produce large numbers of new neurons in response to stroke. The purpose of this review is to provide an updated overview of stroke-induced adult neurogenesis, from a cellular and molecular perspective, to its impact on brain repair and functional recovery.

Citing Articles

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In vivo detection of poststroke cerebral cell proliferation in rodents and humans.

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Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?.

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