Decreased Long Noncoding RNA MIR31HG is Correlated with Poor Prognosis and Contributes to Cell Proliferation in Gastric Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 Dec 23

PMID 26692098

Citations 31

Authors

Feng-Qi Nie

Shijie Ma

Min Xie

Yan-Wen Liu

Wei De

Xiang-Hua Liu

Affiliations

Soon will be listed here.

Abstract

Long noncoding RNAs (lncRNAs) are emerging as key regulators governing fundamental biological processes, and their disorder expression involves in the development of several human cancers. MIR31HG, an lncRNA located in 9p21.3 and 2166 bp in length, has been found to be upregulated in breast cancer and contributes to cell proliferation and invasion. However, the expression pattern and biological function of MIR31HG in gastric cancer are still not well documented. In this study, we found that MIR31HG expression is decreased in gastric cancer tissues and associated with larger tumor size and advanced pathological stage. Patients with lower MIR31HG expression had a relatively poor prognosis. Furthermore, ectopic over-expression of MIR31HG could inhibit gastric cancer (GC) cell proliferation both in vitro and in vivo, while knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. Our findings present that decreased MIR31HG is involved in GC development and could be identified as a poor prognostic biomarker in GC patients.

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References

Ulitsky I, Bartel D . lincRNAs: genomics, evolution, and mechanisms. Cell. 2013; 154(1):26-46. PMC: 3924787. DOI: 10.1016/j.cell.2013.06.020. View

Jung K, Won Y, Kong H, Oh C, Lee D, Lee J . Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2011. Cancer Res Treat. 2014; 46(2):109-23. PMC: 4022819. DOI: 10.4143/crt.2014.46.2.109. View

Khandelwal A, Bacolla A, Vasquez K, Jain A . Long non-coding RNA: A new paradigm for lung cancer. Mol Carcinog. 2015; 54(11):1235-51. DOI: 10.1002/mc.22362. View

Kim W, Sharpless N . The regulation of INK4/ARF in cancer and aging. Cell. 2006; 127(2):265-75. DOI: 10.1016/j.cell.2006.10.003. View

Huang C, Liu D, Nakano J, Yokomise H, Ueno M, Kadota K . E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer. Clin Cancer Res. 2007; 13(23):6938-46. DOI: 10.1158/1078-0432.CCR-07-1539. View

Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A . The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell. 2013; 24(2):206-14. PMC: 4149175. DOI: 10.1016/j.devcel.2012.12.012. View

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H . The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012; 22(9):1775-89. PMC: 3431493. DOI: 10.1101/gr.132159.111. View

Shi Y, Lu J, Zhou J, Tan X, He Y, Ding J . Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. Biochem Biophys Res Commun. 2014; 446(2):448-53. DOI: 10.1016/j.bbrc.2014.02.144. View

10.

Shi X, Sun M, Wu Y, Yao Y, Liu H, Wu G . Post-transcriptional regulation of long noncoding RNAs in cancer. Tumour Biol. 2015; 36(2):503-13. DOI: 10.1007/s13277-015-3106-y. View

11.

Hu Y, Wang J, Qian J, Kong X, Tang J, Wang Y . Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer. Cancer Res. 2014; 74(23):6890-902. DOI: 10.1158/0008-5472.CAN-14-0686. View

12.

DeSantis C, Siegel R, Bandi P, Jemal A . Breast cancer statistics, 2011. CA Cancer J Clin. 2011; 61(6):409-18. DOI: 10.3322/caac.20134. View

13.

Fatima R, Akhade V, Pal D, Rao S . Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets. Mol Cell Ther. 2015; 3:5. PMC: 4469312. View

14.

Thorenoor N, Faltejskova-Vychytilova P, Hombach S, Mlcochova J, Kretz M, Svoboda M . Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. 2015; 7(1):622-37. PMC: 4808022. DOI: 10.18632/oncotarget.5807. View

15.

Gan L, Xu M, Zhang Y, Zhang X, Guo W . Focusing on long noncoding RNA dysregulation in gastric cancer. Tumour Biol. 2014; 36(1):129-41. DOI: 10.1007/s13277-014-2894-9. View

16.

Guttman M, Donaghey J, Carey B, Garber M, Grenier J, Munson G . lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 2011; 477(7364):295-300. PMC: 3175327. DOI: 10.1038/nature10398. View

17.

Yarmishyn A, Kurochkin I . Long noncoding RNAs: a potential novel class of cancer biomarkers. Front Genet. 2015; 6:145. PMC: 4407501. DOI: 10.3389/fgene.2015.00145. View

18.

Harrow J, Frankish A, Gonzalez J, Tapanari E, Diekhans M, Kokocinski F . GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 2012; 22(9):1760-74. PMC: 3431492. DOI: 10.1101/gr.135350.111. View

19.

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi P . A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell. 2011; 146(3):353-8. PMC: 3235919. DOI: 10.1016/j.cell.2011.07.014. View

20.

Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao S . Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell. 2015; 28(4):529-540. PMC: 4777353. DOI: 10.1016/j.ccell.2015.09.006. View