A Concise Approach to Paxilline Indole Diterpenes

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2015 Nov 24

PMID 26593869

Citations 29

Authors

David T George

Eric J Kuenstner

Sergey V Pronin

Affiliations

Soon will be listed here.

Abstract

A synthetic approach to paxilline indole diterpenes is described. The route to the pentacyclic core relies on a new regioselective alkenylation of ketones and a tandem radical addition-aldol reaction sequence to access vicinal quaternary stereocenters. Emindole SB, the simplest member of the family, is synthesized in 11 steps from commercially available material to demonstrate the application of this approach.

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