Directed Hydrogen Atom Transfer for Selective Reactions of Polyenols

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2024 Jun 25

PMID 38917421

Authors

Daniel E Essayan

Matthew J Schubach

Jeanelle M Smoot

Taranee Puri

Sergey V Pronin

Affiliations

Soon will be listed here.

Abstract

Directed hydrogen atom transfer to alkenes is described. The process is catalyzed by iron complexes and allows for the site-selective hydrofunctionalization of polyenols. Experimental data suggest that coordination of the hydroxy group to the iron hydride intermediate plays an important role in preferential engagement of the allylic alcohol motif and provides a new basis for selectivity in radical hydrofunctionalization events. As a proof of concept, β- and γ-amino alcohols are prepared from the corresponding polyenols in a selective manner.

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