The Roles of Lipid and Glucose Metabolism in Modulation of β-amyloid, Tau, and Neurodegeneration in the Pathogenesis of Alzheimer Disease

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2015 Nov 12

PMID 26557086

Citations 72

Authors

Naoyuki Sato

Ryuichi Morishita

Affiliations

Soon will be listed here.

Abstract

Diabetes is a risk factor for Alzheimer disease (AD). Apolipoprotein E (ApoE) and several genes related to AD have recently been identified by genome-wide association studies (GWAS) as being closely linked to lipid metabolism. Lipid metabolism and glucose-energy metabolism are closely related. Here, we review the emerging evidence regarding the roles of lipid and glucose metabolism in the modulation of β-amyloid, tau, and neurodegeneration during the pathogenesis of AD. Disruption of homeostasis of lipid and glucose metabolism affects production and clearance of β-amyloid and tau phosphorylation, and induces neurodegeneration. A more integrated understanding of the interactions among lipid, glucose, and protein metabolism is required to elucidate the pathogenesis of AD and to develop next-generation therapeutic options.

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