Autumn Olive ( Thunb.) Berries Improve Lipid Metabolism and Delay Aging in Middle-Aged

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Mar 28

PMID 38542392

Authors

Yebin Kim

Seonghyeon Nam

Jongbin Lim

Miran Jang

Affiliations

Soon will be listed here.

Abstract

This study evaluated the positive effects of autumn olive berries (AOBs) extract on delaying aging by improving lipid metabolism in middle-aged that had become obese due to a high-glucose (GLU) diet. The total phenolic content and DPPH radical scavenging abilities of freeze-dried AOBs (FAOBs) or spray-dried AOBs (SAOBs) were examined, and FAOBs exhibited better antioxidant activity. HPLC analysis confirmed that catechin is the main phenolic compound of AOBs; its content was 5.95 times higher in FAOBs than in SAOBs. Therefore, FAOBs were used in subsequent in vivo experiments. FAOBs inhibited lipid accumulation in both the young adult and middle-aged groups in a concentration-dependent manner under both normal and 2% GLU conditions. Additionally, FAOBs inhibited ROS accumulation in a concentration-dependent manner under normal and 2% GLU conditions in the middle-aged worms. In particular, FAOB also increased body bending and egg production in middle-aged worms. To confirm the intervention of genetic factors related to lipid metabolism from the effects of FAOB, body lipid accumulation was confirmed using worms deficient in the daf-16, atgl-1, aak-1, and akt-1 genes. Regarding the effect of FAOB on reducing lipid accumulation, the impact was nullified in daf-16-deficient worms under the 2% GLU condition, and nullified in both the daf-16- and atgl-1-deficient worms under fasting conditions. In conclusion, FAOB mediated daf-16 and atgl-1 to regulate lipogenesis and lipolysis in middle-aged worms. Our findings suggest that FAOB improves lipid metabolism in metabolically impaired middle-aged worms, contributing to its age-delaying effect.

Citing Articles

Study on HPLC fingerprint of Saposhnikovia divaricata lipophilic components and anti-aging effects.

Yue X, Xu Y, Sun B, Shang Y, Yu Z, Hu Y Sci Rep. 2024; 14(1):25766.

PMID: 39468240 PMC: 11519334. DOI: 10.1038/s41598-024-75824-0.

References

Kim Y, Lee S, Cho M, Choe S, Jang M . Indian Almond ( Linn.) Leaf Extract Extends Lifespan by Improving Lipid Metabolism and Antioxidant Activity Dependent on AMPK Signaling Pathway in under High-Glucose-Diet Conditions. Antioxidants (Basel). 2024; 13(1). PMC: 10812731. DOI: 10.3390/antiox13010014. View

Silverman G, Luke C, Bhatia S, Long O, Vetica A, Perlmutter D . Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. Pediatr Res. 2008; 65(1):10-8. PMC: 2731241. DOI: 10.1203/PDR.0b013e31819009b0. View

Ory M, Anderson L, Friedman D, Pulczinski J, Eugene N, Satariano W . Cancer prevention among adults aged 45-64 years: setting the stage. Am J Prev Med. 2014; 46(3 Suppl 1):S1-6. PMC: 4536567. DOI: 10.1016/j.amepre.2013.10.027. View

Camell C, Sander J, Spadaro O, Lee A, Nguyen K, Wing A . Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017; 550(7674):119-123. PMC: 5718149. DOI: 10.1038/nature24022. View

Sato N, Morishita R . The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Front Aging Neurosci. 2015; 7:199. PMC: 4615808. DOI: 10.3389/fnagi.2015.00199. View

Wu M, Hu H, Yang L, Yang L . Proteomic analysis of up-accumulated proteins associated with fruit quality during autumn olive (Elaeagnus umbellata) fruit ripening. J Agric Food Chem. 2010; 59(2):577-83. DOI: 10.1021/jf103957k. View

Schreiber R, Xie H, Schweiger M . Of mice and men: The physiological role of adipose triglyceride lipase (ATGL). Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1864(6):880-899. PMC: 6439276. DOI: 10.1016/j.bbalip.2018.10.008. View

Lodhi I, Yin L, Jensen-Urstad A, Funai K, Coleman T, Baird J . Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metab. 2012; 16(2):189-201. PMC: 3467338. DOI: 10.1016/j.cmet.2012.06.013. View

Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L . Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 2017; 16(1):76. PMC: 5387196. DOI: 10.1186/s12943-017-0646-3. View

10.

Cho M, Kim Y, You S, Hwang D, Jang M . Chlorogenic Acid of Resists Oxidative Stress Caused by Aging and Prolongs Healthspan via SKN-1/Nrf2 and DAF-16/FOXO in . Metabolites. 2023; 13(2). PMC: 9959019. DOI: 10.3390/metabo13020224. View

11.

Mennes E, Dungan C, Frendo-Cumbo S, Williamson D, Wright D . Aging-associated reductions in lipolytic and mitochondrial proteins in mouse adipose tissue are not rescued by metformin treatment. J Gerontol A Biol Sci Med Sci. 2013; 69(9):1060-8. DOI: 10.1093/gerona/glt156. View

12.

Kwon J, Kershaw J, Chen C, Komanetsky S, Zhu Y, Guo X . Piceatannol antagonizes lipolysis by promoting autophagy-lysosome-dependent degradation of lipolytic protein clusters in adipocytes. J Nutr Biochem. 2022; 105:108998. PMC: 9133117. DOI: 10.1016/j.jnutbio.2022.108998. View

13.

Nazir N, Zahoor M, Ullah R, Ezzeldin E, Mostafa G . Curative Effect of Catechin Isolated from Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model. Molecules. 2021; 26(1). PMC: 7794731. DOI: 10.3390/molecules26010137. View

14.

Chakrabarti P, Kandror K . FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J Biol Chem. 2009; 284(20):13296-13300. PMC: 2679428. DOI: 10.1074/jbc.C800241200. View

15.

Geng J, Ni Q, Sun W, Li L, Feng X . The links between gut microbiota and obesity and obesity related diseases. Biomed Pharmacother. 2022; 147:112678. DOI: 10.1016/j.biopha.2022.112678. View

16.

Svensk E, Devkota R, Stahlman M, Ranji P, Rauthan M, Magnusson F . Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition. PLoS Genet. 2016; 12(4):e1005982. PMC: 4833288. DOI: 10.1371/journal.pgen.1005982. View

17.

Hodson L, Banerjee R, Rial B, Arlt W, Adiels M, Boren J . Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women. J Am Heart Assoc. 2015; 4(10):e002258. PMC: 4845132. DOI: 10.1161/JAHA.115.002258. View

18.

Alcantar-Fernandez J, Gonzalez-Maciel A, Reynoso-Robles R, Perez Andrade M, Hernandez-Vazquez A, Velazquez-Arellano A . High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. PLoS One. 2019; 14(12):e0226652. PMC: 6917275. DOI: 10.1371/journal.pone.0226652. View

19.

Nazir N, Zahoor M, Nisar M, Khan I, Karim N, Abdel-Halim H . Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach. BMC Complement Altern Med. 2018; 18(1):332. PMC: 6293591. DOI: 10.1186/s12906-018-2381-8. View

20.

Gomes W, Franca F, Denadai M, Andrade J, da Silva Oliveira E, de Brito E . Effect of freeze- and spray-drying on physico-chemical characteristics, phenolic compounds and antioxidant activity of papaya pulp. J Food Sci Technol. 2018; 55(6):2095-2102. PMC: 5976593. DOI: 10.1007/s13197-018-3124-z. View