The Scales and Tales of Myelination: Using Zebrafish and Mouse to Study Myelinating Glia

Overview

Journal Brain Res

Specialty Neurology

Date 2015 Oct 27

PMID 26498880

Citations 31

Authors

Sarah D Ackerman

Kelly R Monk

Affiliations

Soon will be listed here.

Abstract

Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination. This article is part of a Special Issue entitled SI: Myelin Evolution.

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