First Pregnancy, Somatic and Psychological Status of a 4-Year-Old Child Born Following Annexin V TESA Sperm Separation

Overview

Journal AJP Rep

Date 2015 Oct 24

PMID 26495164

Citations 1

Authors

Krzysztof Lukaszuk

Monika Wcislo

Joanna Liss

Anna Stachowicz

Grzegorz Jakiel

Mariusz Lukaszuk

Ewa Pastuszek

Izabela Woclawek-Potocka

Antonio Galvao

Dorota Bialobrzeska

Affiliations

Soon will be listed here.

Abstract

Introduction Sperm DNA integrity is a crucial paternal factor affecting fertilization and pregnancy rates, as well as embryo development. Case The present case report describes the successful pregnancy after testicular sperm aspiration (TESA) combined with intracytoplasmic sperm injection (ICSI) (TESA-ICSI) in a couple where the male presented high sperm DNA fragmentation. In order to sort damaged sperm presenting DNA fragmentation, magnetic activated cell sorting (MACS) with annexin V microbeads (MACS Miltenyi Biotec, Teterow, Germany) was used. Conclusion The authors present the first description of a successful medical case using TESA-ICSI annexin V sperm sorting. Additionally, a follow-up of the child at the age of 4 years old was done.

Citing Articles

Magnetic-activated cell sorting of nonapoptotic spermatozoa with a high DNA fragmentation index improves the live birth rate and decreases transfer cycles of IVF/ICSI.

Mei J, Chen L, Zhu X, Yu W, Gao Q, Sun H Asian J Androl. 2021; 24(4):367-372.

PMID: 34708718 PMC: 9295468. DOI: 10.4103/aja202161.

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