Potential of Biological Processes to Eliminate Antibiotics in Livestock Manure: An Overview

Overview

Journal Animals (Basel)

Date 2015 Oct 20

PMID 26480034

Citations 47

Authors

Daniel I Masse

Noori M Cata Saady

Yan Gilbert

Affiliations

Soon will be listed here.

Abstract

Degrading antibiotics discharged in the livestock manure in a well-controlled bioprocess contributes to a more sustainable and environment-friendly livestock breeding. Although most antibiotics remain stable during manure storage, anaerobic digestion can degrade and remove them to various extents depending on the concentration and class of antibiotic, bioreactor operating conditions, type of feedstock and inoculum sources. Generally, antibiotics are degraded during composting > anaerobic digestion > manure storage > soil. Manure matrix variation influences extraction, quantification, and degradation of antibiotics, but it has not been well investigated. Fractioning of manure-laden antibiotics into liquid and solid phases and its effects on their anaerobic degradation and the contribution of abiotic (physical and chemical) versus biotic degradation mechanisms need to be quantified for various manures, antibiotics types, reactor designs and temperature of operations. More research is required to determine the kinetics of antibiotics' metabolites degradation during anaerobic digestion. Further investigations are required to assess the degradation of antibiotics during psychrophilic anaerobic digestion.

Citing Articles

Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments.

Gudda F, Muloi D, Nganga F, Nolari C, Gao Y, Moodley A NPJ Antimicrob Resist. 2025; 2(1):51.

PMID: 39843536 PMC: 11721419. DOI: 10.1038/s44259-024-00071-2.

Application of Microbiological Screening Tests in Assessment of Environmental Exposure to Antibiotics: Preliminary Studies.

Madej-Knysak D, Adamek E, Kosmider L, Baran W J Xenobiot. 2024; 14(3):1187-1200.

PMID: 39311146 PMC: 11417730. DOI: 10.3390/jox14030067.

Selection for amoxicillin-, doxycycline-, and enrofloxacin-resistant at concentrations lower than the ECOFF in broiler-derived cecal fermentations.

Swinkels A, Fischer E, Korving L, Kusters N, Wagenaar J, Zomer A Microbiol Spectr. 2024; 12(10):e0097024.

PMID: 39269186 PMC: 11448166. DOI: 10.1128/spectrum.00970-24.

Prevalence of multidrug-resistant isolates and virulence gene expression in poultry farms in Jos, Nigeria.

Agusi E, Kabantiyok D, Mkpuma N, Atai R, Okongwu-Ejike C, Bakare E Front Microbiol. 2024; 15:1298582.

PMID: 38933030 PMC: 11199394. DOI: 10.3389/fmicb.2024.1298582.

Bioconversion of cow manure through vermicomposting: effects of tylosin concentration on the weight of worms and manure quality.

Ghandehari Yazdi F, Mokhtari M, Nabi Meibodi M, Sefidkar R, Hatami B, Molavi F Sci Rep. 2024; 14(1):12575.

PMID: 38822086 PMC: 11143363. DOI: 10.1038/s41598-024-62839-w.

References

Hamscher G, Sczesny S, Hoper H, Nau H . Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Anal Chem. 2002; 74(7):1509-18. DOI: 10.1021/ac015588m. View

Teeter J, Meyerhoff R . Aerobic degradation of tylosin in cattle, chicken, and swine excreta. Environ Res. 2003; 93(1):45-51. DOI: 10.1016/s0013-9351(02)00086-5. View

Pan X, Qiang Z, Ben W, Chen M . Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere. 2011; 84(5):695-700. DOI: 10.1016/j.chemosphere.2011.03.022. View

Ingerslev F, Halling-Sorensen B . Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. Ecotoxicol Environ Saf. 2001; 48(3):311-20. DOI: 10.1006/eesa.2000.2026. View

Arikan O, Mulbry W, Rice C . Management of antibiotic residues from agricultural sources: use of composting to reduce chlortetracycline residues in beef manure from treated animals. J Hazard Mater. 2008; 164(2-3):483-9. DOI: 10.1016/j.jhazmat.2008.08.019. View

Xian Q, Hu L, Chen H, Chang Z, Zou H . Removal of nutrients and veterinary antibiotics from swine wastewater by a constructed macrophyte floating bed system. J Environ Manage. 2010; 91(12):2657-61. DOI: 10.1016/j.jenvman.2010.07.036. View

Dolliver H, Gupta S . Antibiotic losses from unprotected manure stockpiles. J Environ Qual. 2008; 37(3):1238-44. DOI: 10.2134/jeq2007.0391. View

Chelliapan S, Wilby T, Sallis P, Yuzir A . Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR). Water Sci Technol. 2011; 63(8):1599-606. DOI: 10.2166/wst.2011.222. View

De Liguoro M, Cibin V, Capolongo F, Halling-Sorensen B, Montesissa C . Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. Chemosphere. 2003; 52(1):203-12. DOI: 10.1016/S0045-6535(03)00284-4. View

10.

Schlusener M, von Arb M, Bester K . Elimination of macrolides, tiamulin, and salinomycin during manure storage. Arch Environ Contam Toxicol. 2006; 51(1):21-8. DOI: 10.1007/s00244-004-0240-8. View

11.

Aust M, Godlinski F, Travis G, Hao X, McAllister T, Leinweber P . Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle. Environ Pollut. 2008; 156(3):1243-51. DOI: 10.1016/j.envpol.2008.03.011. View

12.

Donoho A, Manthey J, OCCOLOWITZ J, Zornes L . Metabolism of monensin in the steer and rat. J Agric Food Chem. 1978; 26(5):1090-5. DOI: 10.1021/jf60219a005. View

13.

Motoyama M, Nakagawa S, Tanoue R, Sato Y, Nomiyama K, Shinohara R . Residues of pharmaceutical products in recycled organic manure produced from sewage sludge and solid waste from livestock and relationship to their fermentation level. Chemosphere. 2011; 84(4):432-8. DOI: 10.1016/j.chemosphere.2011.03.048. View

14.

Wang Q, Bradford S, Zheng W, Yates S . Sulfadimethoxine degradation kinetics in manure as affected by initial concentration, moisture, and temperature. J Environ Qual. 2006; 35(6):2162-9. DOI: 10.2134/jeq2006.0178. View

15.

Chang X, Meyer M, Liu X, Zhao Q, Chen H, Chen J . Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorge Reservoir in China. Environ Pollut. 2010; 158(5):1444-50. DOI: 10.1016/j.envpol.2009.12.034. View

16.

Kim K, Owens G, Ok Y, Park W, Lee D, Kwon S . Decline in extractable antibiotics in manure-based composts during composting. Waste Manag. 2011; 32(1):110-6. DOI: 10.1016/j.wasman.2011.07.026. View

17.

Carballa M, Omil F, Ternes T, Lema J . Fate of pharmaceutical and personal care products (PPCPs) during anaerobic digestion of sewage sludge. Water Res. 2007; 41(10):2139-50. DOI: 10.1016/j.watres.2007.02.012. View

18.

Storteboom H, Kim S, Doesken K, Carlson K, Davis J, Pruden A . Response of antibiotics and resistance genes to high-intensity and low-intensity manure management. J Environ Qual. 2007; 36(6):1695-703. DOI: 10.2134/jeq2007.0006. View

19.

Arikan O . Degradation and metabolization of chlortetracycline during the anaerobic digestion of manure from medicated calves. J Hazard Mater. 2008; 158(2-3):485-90. DOI: 10.1016/j.jhazmat.2008.01.096. View

20.

Ben W, Qiang Z, Adams C, Zhang H, Chen L . Simultaneous determination of sulfonamides, tetracyclines and tiamulin in swine wastewater by solid-phase extraction and liquid chromatography-mass spectrometry. J Chromatogr A. 2008; 1202(2):173-80. DOI: 10.1016/j.chroma.2008.07.014. View