Epigenome-modifying Tools in Asthma

Overview

Journal Epigenomics

Specialty Genetics

Date 2015 Oct 20

PMID 26479310

Citations 27

Authors

Peter O Brook

Mark M Perry

Ian M Adcock

Andrew L Durham

Affiliations

Soon will be listed here.

Abstract

Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.

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