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Ian M Adcock

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Articles 470
Citations 14028
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Recent Articles
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Brown A, Carroll O, Mayall J, Zounemat-Kermani N, Vinzenz S, Gomez H, et al.
Mucosal Immunol . 2025 Feb; PMID: 40021011
Females are disproportionately affected by asthma. An increased understanding of how female sex hormones influence key pathophysiological processes that underpin asthma may identify new, more effective asthma therapies, particularly for...
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Montuschi P, Adcock I
J Pharmacol Exp Ther . 2025 Feb; 392(3):100045. PMID: 39969271
No abstract available.
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Kuks P, Kole T, Kraft M, Siddiqui S, Fabbri L, Rabe K, et al.
ERJ Open Res . 2025 Feb; 11(1). PMID: 39963164
Introduction: Neutrophilic asthma has been suggested to be a clinically distinct phenotype characterised by more severe airflow obstruction and higher exacerbation risk. However, this has only been assessed in few...
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Kang Y, Kim H, Lee C, Jung J, Moon J, Park S, et al.
World Allergy Organ J . 2025 Feb; 18(1):100990. PMID: 39896201
Background: Eosinophils are crucial in allergic inflammation, and their correlation with asthma severity has made them a focal point in predicting treatment outcomes. Blood eosinophil count is a commonly utilized...
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Tejwani V, Wang R, Villabona-Rueda A, Suresh K, Wu T, Adcock I, et al.
Am J Physiol Lung Cell Mol Physiol . 2025 Jan; 328(3):L372-L378. PMID: 39868576
Obesity is a risk factor for asthma morbidity, associated with less responsiveness to inhaled corticosteroids. CD4+ T cells are central to the immunology of asthma and may contribute to the...
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Liu G, Hsu A, Geirnaert S, Cong C, Nair P, Shen S, et al.
Mol Ther . 2025 Jan; 33(3):917-932. PMID: 39838644
Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in chronic obstructive pulmonary disease (COPD) is unknown. We show that VTN regulates tissue remodeling through...
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Reddy K, Xenaki D, Adcock I, Oliver B, Zakarya R
Cells . 2025 Jan; 14(1. PMID: 39791732
Chronic obstructive pulmonary disease (COPD) is characterized by progressive and incurable airflow obstruction and chronic inflammation. Both TGF-β1 and CXCL8 have been well described as fundamental to COPD progression. DNA...
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Daud T, Roberts S, Kermani N, Richardson M, Heaney L, Adcock I, et al.
Allergy . 2025 Jan; PMID: 39749571
Background: Airway remodelling is a feature of severe asthma with airway epithelial damage observed frequently. We evaluated the role of WNT5a and TGF-β in asthmatic airway biopsies and in sputum...
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Meys R, Franssen F, van t Hul A, Bakke P, Caruso M, Dahlen B, et al.
Health Qual Life Outcomes . 2024 Dec; 22(1):109. PMID: 39707320
Rationale: Knowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited. Objectives: To assess whether and to what extent asthma exacerbations affect changes in PROMS...