Sex Differences and the Role of IL-10 in Ischemic Stroke Recovery

Overview

Journal Biol Sex Differ

Publisher Biomed Central

Specialties Biology
Physiology

Date 2015 Oct 14

PMID 26462256

Citations 19

Authors

Sarah E Conway

Meaghan Roy-OReilly

Brett Friedler

Ilene Staff

Gilbert Fortunato

Louise D McCullough

Affiliations

Soon will be listed here.

Abstract

Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4(+) helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-10 levels after ischemic stroke. In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent predictor of functional outcomes. This suggests that higher serum IL-10 levels may reflect factors that interact with sex such as age and stroke severity.

Citing Articles

Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke.

Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S J Womens Health (Larchmt). 2024; 33(10):1378-1384.

PMID: 38946610 PMC: 11564668. DOI: 10.1089/jwh.2023.1133.

Gut-Brain Axis: Focus on Sex Differences in Neuroinflammation.

Caldarelli M, Rio P, Marrone A, Ocarino F, Chiantore M, Candelli M Int J Mol Sci. 2024; 25(10).

PMID: 38791415 PMC: 11120930. DOI: 10.3390/ijms25105377.

Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study.

Lukasik M, Telec M, Kazmierski R, Wojtasz I, Andrzejewska-Gorczynska N, Kociemba W J Neuroinflammation. 2023; 20(1):275.

PMID: 37996909 PMC: 10666369. DOI: 10.1186/s12974-023-02957-w.

Immune regulation based on sex differences in ischemic stroke pathology.

Niu P, Li L, Zhang Y, Su Z, Wang B, Liu H Front Immunol. 2023; 14:1087815.

PMID: 36793730 PMC: 9923235. DOI: 10.3389/fimmu.2023.1087815.

The immunopathology of B lymphocytes during stroke-induced injury and repair.

Malone M, Ujas T, Britsch D, Cotter K, Poinsatte K, Stowe A Semin Immunopathol. 2022; 45(3):315-327.

PMID: 36446955 PMC: 9708141. DOI: 10.1007/s00281-022-00971-3.

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