» Articles » PMID: 36793730

Immune Regulation Based on Sex Differences in Ischemic Stroke Pathology

Overview
Journal Front Immunol
Date 2023 Feb 16
PMID 36793730
Authors
Affiliations
Soon will be listed here.
Abstract

Ischemic stroke is one of the world's leading causes of death and disability. It has been established that gender differences in stroke outcomes prevail, and the immune response after stroke is an important factor affecting patient outcomes. However, gender disparities lead to different immune metabolic tendencies closely related to immune regulation after stroke. The present review provides a comprehensive overview of the role and mechanism of immune regulation based on sex differences in ischemic stroke pathology.

Citing Articles

Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug.

Okabe N, Wei X, Abumeri F, Batac J, Hovanesyan M, Dai W Nat Commun. 2025; 16(1):2556.

PMID: 40089466 DOI: 10.1038/s41467-025-57860-0.


Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice.

Kang S, Lee J, Ali D, Choi S, Nesbitt J, Min P Sci Rep. 2024; 14(1):23989.

PMID: 39402264 PMC: 11473946. DOI: 10.1038/s41598-024-75202-w.


J-shaped associations of pan-immune-inflammation value and systemic inflammation response index with stroke among American adults with hypertension: evidence from NHANES 1999-2020.

Chen J, Luo C, Tan D, Li Y Front Neurol. 2024; 15:1417863.

PMID: 39144717 PMC: 11322096. DOI: 10.3389/fneur.2024.1417863.


Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.

Zhou C, Qiu S, Wang F, Liu Y, Hu W, Yang M Front Pharmacol. 2024; 15:1449452.

PMID: 39139639 PMC: 11320715. DOI: 10.3389/fphar.2024.1449452.


Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype.

Chelluboina B, Cho T, Park J, Mehta S, Bathula S, Jeong S Neurochem Int. 2024; 178:105795.

PMID: 38908519 PMC: 11296926. DOI: 10.1016/j.neuint.2024.105795.


References
1.
Vassiliadou N, Tucker L, Anderson D . Progesterone-induced inhibition of chemokine receptor expression on peripheral blood mononuclear cells correlates with reduced HIV-1 infectability in vitro. J Immunol. 1999; 162(12):7510-8. View

2.
Rettberg J, Yao J, Brinton R . Estrogen: a master regulator of bioenergetic systems in the brain and body. Front Neuroendocrinol. 2013; 35(1):8-30. PMC: 4024050. DOI: 10.1016/j.yfrne.2013.08.001. View

3.
Bodhankar S, Lapato A, Chen Y, Vandenbark A, Saugstad J, Offner H . Role for microglia in sex differences after ischemic stroke: importance of M2. Metab Brain Dis. 2015; 30(6):1515-29. PMC: 4644102. DOI: 10.1007/s11011-015-9714-9. View

4.
Matthews J, Hay R . Regulation of the DNA binding activity of NF-kappa B. Int J Biochem Cell Biol. 1995; 27(9):865-79. DOI: 10.1016/1357-2725(95)00071-v. View

5.
Lambertsen K, Gregersen R, Meldgaard M, Clausen B, Heibol E, Ladeby R . A role for interferon-gamma in focal cerebral ischemia in mice. J Neuropathol Exp Neurol. 2004; 63(9):942-55. DOI: 10.1093/jnen/63.9.942. View