ORF8-Related Genetic Evidence for Chinese Horseshoe Bats As the Source of Human Severe Acute Respiratory Syndrome Coronavirus

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2015 Oct 4

PMID 26433221

Citations 56

Authors

Zhiqiang Wu

Li Yang

Xianwen Ren

Junpeng Zhang

Fan Yang

Shuyi Zhang

Qi Jin

Affiliations

Soon will be listed here.

Abstract

Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)-like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.

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