Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

Overview

Journal Science

Specialty Science

Date 2003 Sep 6

PMID 12958366

Citations 1238

Authors

Y Guan

B J Zheng

Y Q He

X L Liu

Z X Zhuang

C L Cheung

S W Luo

P H Li

L J Zhang

Y J Guan

K M Butt

K L Wong

K W Chan

W Lim

K F Shortridge

K Y Yuen

J S M Peiris

L L M Poon

Affiliations

Soon will be listed here.

Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

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