Control of Drosophila Type I and Type II Central Brain Neuroblast Proliferation by Bantam MicroRNA

Overview

Journal Development

Specialty Biology

Date 2015 Sep 24

PMID 26395494

Citations 20

Authors

Ruifen Weng

Stephen M Cohen

Affiliations

Soon will be listed here.

Abstract

Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.

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