The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder

Overview

Journal Transplantation

Specialty General Surgery

Date 2015 Sep 11

PMID 26356179

Citations 17

Authors

Michael E Seifert

Keith A Hruska

Affiliations

Soon will be listed here.

Abstract

The last 25 years have been characterized by dramatic improvements in short-term patient and allograft survival after kidney transplantation. Long-term patient and allograft survival remains limited by cardiovascular disease and chronic allograft injury, among other factors. Cardiovascular disease remains a significant contributor to mortality in native chronic kidney disease as well as cardiovascular mortality in chronic kidney disease more than doubles that of the general population. The chronic kidney disease (CKD)-mineral bone disorder (MBD) is a syndrome recently coined to embody the biochemical, skeletal, and cardiovascular pathophysiology that results from disrupting the complex systems biology between the kidney, skeleton, and cardiovascular system in native and transplant kidney disease. The CKD-MBD is a unique kidney disease-specific syndrome containing novel cardiovascular risk factors, with an impact reaching far beyond traditional notions of renal osteodystrophy and hyperparathyroidism. This overview reviews current knowledge of the pathophysiology of the CKD-MBD, including emerging concepts surrounding the importance of circulating pathogenic factors released from the injured kidney that directly cause cardiovascular disease in native and transplant chronic kidney disease, with potential application to mechanisms of chronic allograft injury and vasculopathy.

Citing Articles

Vascular calcification progression and its association with mineral and bone disorder in kidney transplant recipients.

Sun L, Huang Z, Fei S, Ni B, Wang Z, Chen H Ren Fail. 2023; 45(2):2276382.

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Chronic kidney disease in children: an update.

Cirillo L, De Chiara L, Innocenti S, Errichiello C, Romagnani P, Becherucci F Clin Kidney J. 2023; 16(10):1600-1611.

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Validation of a Phosphorus Food Frequency Questionnaire in Patients with Kidney Failure Undertaking Dialysis.

Beer J, Lambert K, Lim W, Bettridge E, Woodward F, Boudville N Nutrients. 2023; 15(7).

PMID: 37049551 PMC: 10096831. DOI: 10.3390/nu15071711.

The Role of Alterations in Alpha-Klotho and FGF-23 in Kidney Transplantation and Kidney Donation.

Gupta M, Orozco G, Rao M, Gedaly R, Malluche H, Neyra J Front Med (Lausanne). 2022; 9:803016.

PMID: 35602513 PMC: 9121872. DOI: 10.3389/fmed.2022.803016.

Malnutrition-Inflammation Complex Syndrome and Bone Fractures and Cardiovascular Disease Events in Patients Undergoing Hemodialysis: The Q-Cohort Study.

Yamada S, Arase H, Yoshida H, Kitamura H, Tokumoto M, Taniguchi M Kidney Med. 2022; 4(3):100408.

PMID: 35386605 PMC: 8978069. DOI: 10.1016/j.xkme.2022.100408.

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