Vitamin D Insufficiency: Implications for the Immune System

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2010 Feb 25

PMID 20180136

Citations 48

Authors

Femke Baeke

Conny Gysemans

Hannelie Korf

Chantal Mathieu

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) is characterized by a loss of kidney function and dysregulation of vitamin D metabolism. Well known are the defects in final activation of vitamin D to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], resulting in renal osteodystrophy. However, in recent years, 1,25(OH)(2)D(3) has been identified as having effects far beyond calcium and bone metabolism. In this review, specific attention is given to the effects of 1,25(OH)(2)D(3) on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function.

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