Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Sep 9

PMID 26347885

Citations 18

Authors

Hai-Yang Zhao

Jiang Wu

Jing-Jing Zhu

Ze-Cong Xiao

Chao-Chao He

Hong-Xue Shi

Xiao-Kun Li

Shu-Lin Yang

Jian Xiao

Affiliations

Soon will be listed here.

Abstract

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor's application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.

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