PDGF Function in Diverse Neural Crest Cell Populations

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2010 Jul 27

PMID 20657170

Citations 28

Authors

Christopher L Smith

Michelle D Tallquist

Affiliations

Soon will be listed here.

Abstract

Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryonic development. One of these migratory cell populations is the neural crest, which forms cranial bone and mesenchyme, sympathetic neurons and ganglia, melanocytes, and smooth muscle. Mice with disruption of PDGF signaling exhibit defects in some of these neural crest derivatives including the palate, aortic arch, salivary gland, and thymus. Although many of these neural crest defects were identified many years ago, the mechanism of action of PDGF in neural crest remains controversial. In this review, we examine the current knowledge of PDGF function during neural crest cell (NCC) development, focusing on its role in the formation of different neural crest-derived tissues and the implications for PDGF receptors in NCC-related human birth defects.

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References

Schatteman G, Bork T, Bowen-Pope D, Weston J . A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development. 1992; 115(1):133-42. DOI: 10.1242/dev.115.1.133. View

Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B . A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004; 36(10):1111-6. DOI: 10.1038/ng1415. View

Tallquist M, Weismann K, Hellstrom M, Soriano P . Early myotome specification regulates PDGFA expression and axial skeleton development. Development. 2000; 127(23):5059-70. DOI: 10.1242/dev.127.23.5059. View

Verberne M, Gittenberger-de Groot A, Poelmann R . Lineage and development of the parasympathetic nervous system of the embryonic chick heart. Anat Embryol (Berl). 1998; 198(3):171-84. DOI: 10.1007/s004290050175. View

Jenkinson W, Rossi S, Parnell S, Jenkinson E, Anderson G . PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches. Blood. 2006; 109(3):954-60. DOI: 10.1182/blood-2006-05-023143. View

Claesson-Welsh L, Eriksson A, Westermark B, Heldin C . cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A. 1989; 86(13):4917-21. PMC: 297526. DOI: 10.1073/pnas.86.13.4917. View

Takakura N, Yoshida H, Ogura Y, Kataoka H, Nishikawa S . PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J Histochem Cytochem. 1997; 45(6):883-93. DOI: 10.1177/002215549704500613. View

Kang J, Gu Y, Li P, Johnson B, Sucov H, Thomas P . PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008; 237(3):692-701. DOI: 10.1002/dvdy.21469. View

Duttlinger R, Manova K, Berrozpe G, Chu T, DeLeon V, Timokhina I . The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc Natl Acad Sci U S A. 1995; 92(9):3754-8. PMC: 42040. DOI: 10.1073/pnas.92.9.3754. View

10.

Stoller J, Epstein J . Cardiac neural crest. Semin Cell Dev Biol. 2005; 16(6):704-15. DOI: 10.1016/j.semcdb.2005.06.004. View

11.

Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin C . PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol. 2001; 3(5):512-6. DOI: 10.1038/35074588. View

12.

Hammacher A, Mellstrom K, Heldin C, Westermark B . Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J. 1989; 8(9):2489-95. PMC: 401239. DOI: 10.1002/j.1460-2075.1989.tb08385.x. View

13.

Stephenson D, Mercola M, Anderson E, Wang C, Stiles C, Bowen-Pope D . Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A. 1991; 88(1):6-10. PMC: 50736. DOI: 10.1073/pnas.88.1.6. View

14.

Santagati F, Rijli F . Cranial neural crest and the building of the vertebrate head. Nat Rev Neurosci. 2003; 4(10):806-18. DOI: 10.1038/nrn1221. View

15.

Ross R, GLOMSET J, Kariya B, Harker L . A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974; 71(4):1207-10. PMC: 388193. DOI: 10.1073/pnas.71.4.1207. View

16.

Schatteman G, van Koppen A, Weston J, Bowen-Pope D . Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development. 1992; 115(1):123-31. DOI: 10.1242/dev.115.1.123. View

17.

Kanakaraj P, Raj S, Khan S, Bishayee S . Ligand-induced interaction between alpha- and beta-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation. Biochemistry. 1991; 30(7):1761-7. DOI: 10.1021/bi00221a005. View

18.

Xu X, Bringas Jr P, Soriano P, Chai Y . PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev Dyn. 2004; 232(1):75-84. DOI: 10.1002/dvdy.20197. View

19.

van den Akker N, Winkel L, Nisancioglu M, Maas S, Wisse L, Armulik A . PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation. Dev Dyn. 2008; 237(2):494-503. DOI: 10.1002/dvdy.21436. View

20.

Schneider L, Clement C, Teilmann S, Pazour G, Hoffmann E, Satir P . PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol. 2005; 15(20):1861-6. DOI: 10.1016/j.cub.2005.09.012. View