Enhancing Regenerative Approaches with Nanoparticles

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2017 Apr 14

PMID 28404870

Citations 28

Authors

Sabine van Rijt

Pamela Habibovic

Affiliations

Soon will be listed here.

Abstract

In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticle-based methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

Citing Articles

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References

Jayabalan M, Shalumon K, Mitha M, Ganesan K, Epple M . Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications. Acta Biomater. 2009; 6(3):763-75. DOI: 10.1016/j.actbio.2009.09.015. View

Wegner K, Hildebrandt N . Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors. Chem Soc Rev. 2015; 44(14):4792-834. DOI: 10.1039/c4cs00532e. View

Uskokovic V . When 1+1>2: Nanostructured composites for hard tissue engineering applications. Mater Sci Eng C Mater Biol Appl. 2015; 57:434-51. PMC: 4567690. DOI: 10.1016/j.msec.2015.07.050. View

Warabi S, Tachibana Y, Kumegawa M, Hakeda Y . Dexamethasone inhibits bone resorption by indirectly inducing apoptosis of the bone-resorbing osteoclasts via the action of osteoblastic cells. Cytotechnology. 2008; 35(1):25-34. PMC: 3466617. DOI: 10.1023/A:1008159332152. View

Piktel E, Niemirowicz K, Watek M, Wollny T, Deptula P, Bucki R . Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy. J Nanobiotechnology. 2016; 14(1):39. PMC: 4881065. DOI: 10.1186/s12951-016-0193-x. View

Gong T, Xie J, Liao J, Zhang T, Lin S, Lin Y . Nanomaterials and bone regeneration. Bone Res. 2015; 3:15029. PMC: 4639780. DOI: 10.1038/boneres.2015.29. View

Loebinger M, Kyrtatos P, Turmaine M, Price A, Pankhurst Q, Lythgoe M . Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Res. 2009; 69(23):8862-7. PMC: 2833408. DOI: 10.1158/0008-5472.CAN-09-1912. View

Ngen E, Wang L, Kato Y, Krishnamachary B, Zhu W, Gandhi N . Imaging transplanted stem cells in real time using an MRI dual-contrast method. Sci Rep. 2015; 5:13628. PMC: 4556978. DOI: 10.1038/srep13628. View

Hsieh S, Wang F, Hung S, Chen Y, Wang Y . The internalized CdSe/ZnS quantum dots impair the chondrogenesis of bone marrow mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 2006; 79(1):95-101. DOI: 10.1002/jbm.b.30517. View

10.

Liu L, Zhou X, Xu Y, Zhang W, Liu C, Wang X . Controlled release of growth factors for regenerative medicine. Curr Pharm Des. 2015; 21(12):1627-32. DOI: 10.2174/1381612821666150115154602. View

11.

Waite C, Roth C . Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities. Crit Rev Biomed Eng. 2012; 40(1):21-41. PMC: 3639314. DOI: 10.1615/critrevbiomedeng.v40.i1.20. View

12.

Schafer R, Kehlbach R, Muller M, Bantleon R, Kluba T, Ayturan M . Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability. Cytotherapy. 2009; 11(1):68-78. DOI: 10.1080/14653240802666043. View

13.

Vo T, Kasper F, Mikos A . Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev. 2012; 64(12):1292-309. PMC: 3358582. DOI: 10.1016/j.addr.2012.01.016. View

14.

Tran N, Webster T . Increased osteoblast functions in the presence of hydroxyapatite-coated iron oxide nanoparticles. Acta Biomater. 2010; 7(3):1298-306. DOI: 10.1016/j.actbio.2010.10.004. View

15.

Shah S, Sasmal P, Lee K . Photo-triggerable Hydrogel-Nanoparticle Hybrid Scaffolds for Remotely Controlled Drug Delivery. J Mater Chem B. 2015; 2(44):7685-7693. PMC: 4285771. DOI: 10.1039/C4TB01436G. View

16.

Zhang S, Kucharski C, Doschak M, Sebald W, Uludag H . Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery. Biomaterials. 2009; 31(5):952-63. DOI: 10.1016/j.biomaterials.2009.10.011. View

17.

Street J, Bao M, deGuzman L, Bunting S, Peale Jr F, Ferrara N . Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002; 99(15):9656-61. PMC: 124965. DOI: 10.1073/pnas.152324099. View

18.

Song Y, Ku J . Monitoring transplanted human mesenchymal stem cells in rat and rabbit bladders using molecular magnetic resonance imaging. Neurourol Urodyn. 2007; 26(4):584-593. DOI: 10.1002/nau.20351. View

19.

Zhang Y, Wei L, Miron R, Shi B, Bian Z . Anabolic bone formation via a site-specific bone-targeting delivery system by interfering with semaphorin 4D expression. J Bone Miner Res. 2014; 30(2):286-96. DOI: 10.1002/jbmr.2322. View

20.

Kong Z, Lin J, Yu M, Yu L, Li J, Weng W . Enhanced loading and controlled release of rhBMP-2 in thin mineralized collagen coatings with the aid of chitosan nanospheres and its biological evaluations. J Mater Chem B. 2020; 2(28):4572-4582. DOI: 10.1039/c4tb00404c. View