Novel Plasmid-borne Multidrug Resistance Gene Cluster Including Lsa(E) from a Linezolid-resistant Enterococcus Faecium Isolate of Swine Origin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2015 Sep 2

PMID 26324271

Citations 14

Authors

Hongbin Si

Wan-Jiang Zhang

Shengbo Chu

Xiu-Mei Wang

Lei Dai

Xin Hua

Zhimin Dong

Stefan Schwarz

Siguo Liu

Affiliations

Soon will be listed here.

Abstract

A novel nonconjugative plasmid of 28,489 bp from a porcine linezolid-resistant Enterococcus faecium isolate was completely sequenced. This plasmid harbored a novel type of multiresistance gene cluster that comprised the resistance genes lnu(B), lsa(E), spw, aadE, aphA3, and two copies of erm(B), which account for resistance to macrolides, lincosamides, streptogramins, pleuromutilins, streptomycin, spectinomycin, and kanamycin/neomycin. Structural comparisons suggested that this plasmid might have developed from other enterococcal plasmids by insertion element (IS)-mediated interplasmid recombination processes.

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