Building a Ninefold Symmetrical Barrel: Structural Dissections of Centriole Assembly

Overview

Journal Open Biol

Specialties Biology
Cell Biology
Molecular Biology

Date 2015 Aug 14

PMID 26269428

Citations 3

Authors

Gang Dong

Affiliations

Soon will be listed here.

Abstract

Centrioles are short microtubule-based organelles with a conserved ninefold symmetry. They are essential for both centrosome formation and cilium biogenesis in most eukaryotes. A core set of five centriolar proteins has been identified and their sequential recruitment to procentrioles has been established. However, structures at atomic resolution for most of the centriolar components were scarce, and the underlying molecular mechanisms for centriole assembly had been a mystery--until recently. In this review, I briefly summarize recent advancements in high-resolution structural characterization of the core centriolar components and discuss perspectives in the field.

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