Inflammatory Group 2 Innate Lymphoid Cells

Overview

Journal Int Immunol

Specialty Allergy & Immunology

Date 2015 Aug 2

PMID 26232596

Citations 57

Authors

Yuefeng Huang

William E Paul

Affiliations

Soon will be listed here.

Abstract

Group 2 innate lymphoid cells (ILC2 cells) are able to produce type 2 cytokines and to mediate type 2 immune protection and tissue homeostasis. ILC2 cells have often been considered to be a single set of cells that respond to IL-33 and/or IL-25. Recent evidence now indicates that ILC2 cells can be grouped into two distinct subsets: homeostatic or natural ILC2s (nILC2 cells); and inflammatory ILC2 cells (iILC2 cells). nILC2 cells reside in barrier tissues and primarily respond to IL-33. They play critical roles not only in immune protection but also in tissue repair and beige fat biogenesis. iILC2 cells are not present in peripheral tissues in the steady state but can be elicited at many sites by helminth infection or IL-25 treatment. IL-25-elicited ilLC2 cells act as transient ILC progenitors with multipotency. They can be mobilized by distinct types of infections to develop into nILC2-like or ILC3-like cells, functioning in corresponding immune responses. The demonstration of the existence of iILC2 cells adds to our understanding of the complexity of ILC2 biology and makes necessary an analysis of the relationship between nILC2 cells and iILC2 cells.

Citing Articles

Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling.

Lim M, Kim T, Kim H, Jang B, Myung J, Kim H Cell Mol Immunol. 2024; 22(1):97-110.

PMID: 39653767 PMC: 11685411. DOI: 10.1038/s41423-024-01242-x.

Tissue microenvironment induces tissue specificity of ILC2.

Qin M, Fang Y, Zheng Q, Peng M, Wang L, Sang X Cell Death Discov. 2024; 10(1):324.

PMID: 39013890 PMC: 11252336. DOI: 10.1038/s41420-024-02096-y.

B-1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease.

Meher A, McNamara C Immunol Rev. 2024; 324(1):95-103.

PMID: 38747455 PMC: 11262958. DOI: 10.1111/imr.13342.

Revolutionizing Gastric Cancer Prevention: Novel Insights on Gastric Mucosal Inflammation-Cancer Transformation and Chinese Medicine.

Liu L, Fan X, Tang X Chin J Integr Med. 2024; .

PMID: 38676828 DOI: 10.1007/s11655-024-3806-5.

ILC2-mediated immune crosstalk in chronic (vascular) inflammation.

Kral M, van der Vorst E, Surnov A, Weber C, Doring Y Front Immunol. 2024; 14:1326440.

PMID: 38179045 PMC: 10765502. DOI: 10.3389/fimmu.2023.1326440.

References

Allen J, Sutherland T . Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin. Semin Immunol. 2014; 26(4):329-40. PMC: 4179909. DOI: 10.1016/j.smim.2014.06.003. View

Hurst S, Muchamuel T, Gorman D, Gilbert J, Clifford T, Kwan S . New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002; 169(1):443-53. DOI: 10.4049/jimmunol.169.1.443. View

Constantinides M, McDonald B, Verhoef P, Bendelac A . A committed precursor to innate lymphoid cells. Nature. 2014; 508(7496):397-401. PMC: 4003507. DOI: 10.1038/nature13047. View

Liang H, Reinhardt R, Bando J, Sullivan B, Ho I, Locksley R . Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011; 13(1):58-66. PMC: 3242938. DOI: 10.1038/ni.2182. View

Stanya K, Jacobi D, Liu S, Bhargava P, Dai L, Gangl M . Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2012; 123(1):261-71. PMC: 3533296. DOI: 10.1172/JCI64941. View

Drake L, Iijima K, Kita H . Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice. Allergy. 2014; 69(10):1300-7. PMC: 4160406. DOI: 10.1111/all.12446. View

Hams E, Locksley R, McKenzie A, Fallon P . Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013; 191(11):5349-53. PMC: 3847854. DOI: 10.4049/jimmunol.1301176. View

Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H . Critical role of p38 and GATA3 in natural helper cell function. J Immunol. 2013; 191(4):1818-26. PMC: 3765427. DOI: 10.4049/jimmunol.1300379. View

Klein Wolterink R, Serafini N, van Nimwegen M, Vosshenrich C, de Bruijn M, Fonseca Pereira D . Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A. 2013; 110(25):10240-5. PMC: 3690884. DOI: 10.1073/pnas.1217158110. View

10.

Voehringer D, Reese T, Huang X, Shinkai K, Locksley R . Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006; 203(6):1435-46. PMC: 2118302. DOI: 10.1084/jem.20052448. View

11.

Spits H, Cupedo T . Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol. 2012; 30:647-75. DOI: 10.1146/annurev-immunol-020711-075053. View

12.

Salimi M, Barlow J, Saunders S, Xue L, Gutowska-Owsiak D, Wang X . A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013; 210(13):2939-50. PMC: 3865470. DOI: 10.1084/jem.20130351. View

13.

Fallon P, Ballantyne S, Mangan N, Barlow J, Dasvarma A, Hewett D . Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006; 203(4):1105-16. PMC: 2118283. DOI: 10.1084/jem.20051615. View

14.

Bartemes K, Kephart G, Fox S, Kita H . Enhanced innate type 2 immune response in peripheral blood from patients with asthma. J Allergy Clin Immunol. 2014; 134(3):671-678.e4. PMC: 4149890. DOI: 10.1016/j.jaci.2014.06.024. View

15.

Shaw J, Fakhri S, Citardi M, Porter P, Corry D, Kheradmand F . IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2013; 188(4):432-9. PMC: 5448506. DOI: 10.1164/rccm.201212-2227OC. View

16.

Yang Q, Monticelli L, Saenz S, Chi A, Sonnenberg G, Tang J . T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013; 38(4):694-704. PMC: 4029843. DOI: 10.1016/j.immuni.2012.12.003. View

17.

Li D, Guabiraba R, Besnard A, Komai-Koma M, Jabir M, Zhang L . IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J Allergy Clin Immunol. 2014; 134(6):1422-1432.e11. PMC: 4258609. DOI: 10.1016/j.jaci.2014.05.011. View

18.

Oliphant C, Hwang Y, Walker J, Salimi M, Wong S, Brewer J . MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity. 2014; 41(2):283-95. PMC: 4148706. DOI: 10.1016/j.immuni.2014.06.016. View

19.

Turner J, Morrison P, Wilhelm C, Wilson M, Ahlfors H, Renauld J . IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med. 2013; 210(13):2951-65. PMC: 3865473. DOI: 10.1084/jem.20130071. View

20.

Gentek R, Munneke J, Helbig C, Blom B, Hazenberg M, Spits H . Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2. Front Immunol. 2013; 4:334. PMC: 3804867. DOI: 10.3389/fimmu.2013.00334. View