Frequency and Topography of Cerebral Microbleeds in Dementia with Lewy Bodies Compared to Alzheimer's Disease

Overview

Journal Parkinsonism Relat Disord

Specialty Neurology

Date 2015 Jul 25

PMID 26205074

Citations 12

Authors

Ipek Gungor

Lidia Sarro

Jonathan Graff-Radford

Samantha M Zuk

Nirubol Tosakulwong

Scott A Przybelski

Tim Lesnick

Bradley F Boeve

Tanis J Ferman

Glenn E Smith

David S Knopman

Massimo Filippi

Ronald C Petersen

Clifford R Jack Jr

Kejal Kantarci

Affiliations

Soon will be listed here.

Abstract

Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD).

Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs.

Results: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05).

Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.

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References

Kantarci K, Lowe V, Boeve B, Weigand S, Senjem M, Przybelski S . Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging. 2011; 33(9):2091-105. PMC: 3288845. DOI: 10.1016/j.neurobiolaging.2011.09.024. View

Vernooij M, van der Lugt A, Ikram M, Wielopolski P, Niessen W, Hofman A . Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008; 70(14):1208-14. DOI: 10.1212/01.wnl.0000307750.41970.d9. View

Sperling R, Salloway S, Brooks D, Tampieri D, Barakos J, Fox N . Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol. 2012; 11(3):241-9. PMC: 4063417. DOI: 10.1016/S1474-4422(12)70015-7. View

Sperling R, Jack Jr C, Black S, Frosch M, Greenberg S, Hyman B . Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement. 2011; 7(4):367-85. PMC: 3693547. DOI: 10.1016/j.jalz.2011.05.2351. View

Johnson K, Gregas M, Becker J, Kinnecom C, Salat D, Moran E . Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol. 2007; 62(3):229-34. DOI: 10.1002/ana.21164. View

Burack M, Hartlein J, Flores H, Taylor-Reinwald L, Perlmutter J, Cairns N . In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology. 2009; 74(1):77-84. PMC: 2809026. DOI: 10.1212/WNL.0b013e3181c7da8e. View

Pettersen J, Sathiyamoorthy G, Gao F, Szilagyi G, Nadkarni N, St George-Hyslop P . Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol. 2008; 65(6):790-5. DOI: 10.1001/archneur.65.6.790. View

Werring D, Sperling R . Inflammatory cerebral amyloid angiopathy and amyloid-modifying therapies: variations on the same ARIA?. Ann Neurol. 2013; 73(4):439-41. DOI: 10.1002/ana.23891. View

Nagasawa J, Kiyozaka T, Ikeda K . Prevalence and clinicoradiological analyses of patients with Alzheimer disease coexisting multiple microbleeds. J Stroke Cerebrovasc Dis. 2014; 23(9):2444-9. DOI: 10.1016/j.jstrokecerebrovasdis.2014.05.036. View

10.

Kantarci K, Gunter J, Tosakulwong N, Weigand S, Senjem M, Petersen R . Focal hemosiderin deposits and β-amyloid load in the ADNI cohort. Alzheimers Dement. 2013; 9(5 Suppl):S116-23. PMC: 3770782. DOI: 10.1016/j.jalz.2012.10.011. View

11.

Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N . Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002; 15(1):273-89. DOI: 10.1006/nimg.2001.0978. View

12.

Attems J, Jellinger K, Lintner F . Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2005; 110(3):222-31. DOI: 10.1007/s00401-005-1064-y. View

13.

Cordonnier C, Salman R, Wardlaw J . Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain. 2007; 130(Pt 8):1988-2003. DOI: 10.1093/brain/awl387. View

14.

Charidimou A, Gang Q, Werring D . Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry. 2011; 83(2):124-37. DOI: 10.1136/jnnp-2011-301308. View

15.

Fukui T, Oowan Y, Yamazaki T, Kinno R . Prevalence and clinical implication of microbleeds in dementia with lewy bodies in comparison with microbleeds in Alzheimer's disease. Dement Geriatr Cogn Dis Extra. 2013; 3(1):148-60. PMC: 3670631. DOI: 10.1159/000351423. View

16.

Edison P, Rowe C, Rinne J, Ng S, Ahmed I, Kemppainen N . Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 2008; 79(12):1331-8. DOI: 10.1136/jnnp.2007.127878. View

17.

Yates P, Sirisriro R, Villemagne V, Farquharson S, Masters C, Rowe C . Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease. Neurology. 2011; 77(1):48-54. DOI: 10.1212/WNL.0b013e318221ad36. View

18.

Greenberg S, Vernooij M, Cordonnier C, Viswanathan A, Salman R, Warach S . Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009; 8(2):165-74. PMC: 3414436. DOI: 10.1016/S1474-4422(09)70013-4. View

19.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7):939-44. DOI: 10.1212/wnl.34.7.939. View

20.

McKeith I, Dickson D, Lowe J, Emre M, OBrien J, Feldman H . Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005; 65(12):1863-72. DOI: 10.1212/01.wnl.0000187889.17253.b1. View