Focal Hemosiderin Deposits and β-amyloid Load in the ADNI Cohort

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2013 Feb 5

PMID 23375568

Citations 45

Authors

Kejal Kantarci

Jeffrey L Gunter

Nirubol Tosakulwong

Stephen D Weigand

Matthew S Senjem

Ronald C Petersen

Paul S Aisen

William J Jagust

Michael W Weiner

Clifford R Jack Jr

Affiliations

Soon will be listed here.

Abstract

Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD).

Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with (18)F-florbetapir positron emission tomography.

Results: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P < .001) and β-amyloid load (P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P < .001).

Conclusions: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.

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