Coexpression Networks Identify Brain Region-specific Enhancer RNAs in the Human Brain

Overview

Journal Nat Neurosci

Date 2015 Jul 14

PMID 26167905

Citations 53

Authors

Pu Yao

Peijie Lin

Akira Gokoolparsadh

Amelia Assareh

Mike W C Thang

Irina Voineagu

Affiliations

Soon will be listed here.

Abstract

Despite major progress in identifying enhancer regions on a genome-wide scale, the majority of available data are limited to model organisms and human transformed cell lines. We have identified a robust set of enhancer RNAs (eRNAs) expressed in the human brain and constructed networks assessing eRNA-gene coexpression interactions across human fetal brain and multiple adult brain regions. Our data identify brain region-specific eRNAs and show that enhancer regions expressing eRNAs are enriched for genetic variants associated with autism spectrum disorders.

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