SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

Overview

Journal J Neurosci

Specialty Neurology

Date 2012 Mar 2

PMID 22378879

Citations 78

Authors

Lifang Mu

Lucia Berti

Giacomo Masserdotti

Marcela Covic

Theologos M Michaelidis

Kathrin Doberauer

Katharina Merz

Frederick Rehfeld

Anja Haslinger

Michael Wegner

Elisabeth Sock

Veronique Lefebvre

Sebastien Couillard-Despres

Ludwig Aigner

Benedikt Berninger

D Chichung Lie

Affiliations

Soon will be listed here.

Abstract

Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. Moreover, we demonstrate that SoxC transcription factors target the promoters of genes that are induced on neuronal differentiation of adult NSCs. Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of SoxC factors. These data identify SoxC proteins as essential contributors to the genetic network controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic cells.

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