Heterotopic Ossification: Basic-Science Principles and Clinical Correlates

Overview

Journal J Bone Joint Surg Am

Specialties General Surgery
Orthopedics

Date 2015 Jul 3

PMID 26135077

Citations 149

Authors

Kavitha Ranganathan

Shawn Loder

Shailesh Agarwal

Victor W Wong

Victor C Wong

Jonathan Forsberg

Thomas A Davis

Stewart Wang

Aaron W James

Benjamin Levi

Affiliations

Soon will be listed here.

Abstract

➤ Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.➤ The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification.➤ Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification.➤ Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury.➤ Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.

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