A MicroRNA Code for Prostate Cancer Metastasis

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2015 Jun 16

PMID 26073083

Citations 65

Authors

D Bonci

V Coppola

M Patrizii

A Addario

A Cannistraci

F Francescangeli

R Pecci

G Muto

D Collura

R Bedini

A Zeuner

M Valtieri

S Sentinelli

M S Benassi

M Gallucci

P Carlini

S Piccolo

R De Maria

Affiliations

Soon will be listed here.

Abstract

Although the development of bone metastasis is a major detrimental event in prostate cancer, the molecular mechanisms responsible for bone homing and destruction remain largely unknown. Here we show that loss of miR-15 and miR-16 in cooperation with increased miR-21 expression promote prostate cancer spreading and bone lesions. This combination of microRNA endows bone-metastatic potential to prostate cancer cells. Concomitant loss of miR-15/miR-16 and gain of miR-21 aberrantly activate TGF-β and Hedgehog signaling, that mediate local invasion, distant bone marrow colonization and osteolysis by prostate cancer cells. These findings establish a new molecular circuitry for prostate cancer metastasis that was validated in patients' cohorts. Our data indicate a network of biomarkers and druggable pathways to improve patient treatment.

Citing Articles

The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system.

Sang H, Li L, Zhao Q, Liu Y, Hu J, Niu P Front Oncol. 2024; 14:1358422.

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Hsa-miR-15b-5p/miR-195-5p Controls Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells Through Regulating Indian Hedgehog Expression.

Harimi S, Khansarinejad B, Fesahat F, Mondanizadeh M Appl Biochem Biotechnol. 2023; 196(8):4793-4806.

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The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer.

Camargo J, Viana N, Pimenta R, Guimaraes V, Santos G, Candido P Int J Mol Sci. 2023; 24(19).

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Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated "Omics" Approaches to Explore Measurable Metrics.

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The Bone Microenvironment Soil in Prostate Cancer Metastasis: An miRNA Approach.

Prigol A, Rode M, da Luz Efe F, Saleh N, Creczynski-Pasa T Cancers (Basel). 2023; 15(16).

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