Cathepsins: a New Culprit Behind Abdominal Aortic Aneurysm

Overview

Journal Regen Med Res

Publisher EDP Sciences

Date 2015 May 19

PMID 25984324

Citations 7

Authors

Yi Wang

Chaoshu Tang

Yanwen Qin

Affiliations

Soon will be listed here.

Abstract

Abdominal aortic aneurysm (AAA) is a fatal disease defined as an abdominal aortic diameter of 3.0 cm or more, where the abdominal aorta exceeds the normal diameter by more than 50%. Histopathological changes of AAA mainly include extracellular matrix (ECM) remodeling at the abdominal aorta wall, but there is lack of specific drugs to treat AAA. Recent studies have reported that lysosomal cathepsins could induce vascular remodeling and AAA formation by regulating vascular inflammation, medial smooth muscle cell apoptosis, neovascularization, and protease expression. Thus, cathepsins are expected to become a new therapeutic target for AAA treatment.

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