Matrix Metalloproteinases and Descending Aortic Aneurysms: Parity, Disparity, and Switch

Overview

Journal J Card Surg

Specialties Cardiology & Vascular Diseases
General Surgery

Date 2011 Oct 1

PMID 21958052

Citations 17

Authors

Tom P Theruvath

Jeffrey A Jones

John S Ikonomidis

Affiliations

Soon will be listed here.

Abstract

Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, with emphasis on the parity and disparity between the thoracic and abdominal aorta. Furthermore, the role of embryologic cellular origins and evidence of phenotypic switch will be addressed in terms of how this process alters MMP production during aneurysm development.

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