Embryonic Stem Cells As Sources of Donor-independent Platelets

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2015 May 12

PMID 25961451

Citations 2

Authors

Matthew C Canver

Daniel E Bauer

Stuart H Orkin

Affiliations

Soon will be listed here.

Abstract

The creation of a donor-independent source of platelets has been challenging; however, recent advances show growing promise for alternative platelet sources. Pluripotent stem cells have the capacity to differentiate into mature megakaryocytes with the ability to produce functional platelets. In this issue of JCI, Noh et al. provide a proof-of-principle demonstration that embryonic stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. This study emphasizes the importance of precise regulation of gene expression for regenerative medicine applications.

Citing Articles

Thrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells.

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