In Situ Hematopoiesis: a Regulator of TH2 Cytokine-mediated Immunity and Inflammation at Mucosal Surfaces

Overview

Journal Mucosal Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2015 Mar 19

PMID 25783967

Citations 18

Authors

C C K Hui

K M McNagny

J A Denburg

M C Siracusa

Affiliations

Soon will be listed here.

Abstract

Hematopoiesis refers to the development of blood cells in the body through the differentiation of pluripotent stem cells. Although hematopoiesis is a multifocal process during embryonic development, under homeostatic conditions it occurs exclusively within the bone marrow. There, a limited number of hematopoietic stem cells differentiate into a rapidly proliferating population of lineage-restricted progenitors that serve to replenish circulating blood cells. However, emerging reports now suggest that under inflammatory conditions, alterations in hematopoiesis that occur outside of the bone marrow appear to constitute a conserved mechanism of innate immunity. Moreover, recent reports have identified previously unappreciated pathways that regulate the egress of hematopoietic progenitor cells from the bone marrow, alter their activation status, and skew their developmental potential. These studies suggest that progenitor cells contribute to inflammatory response by undergoing in situ hematopoiesis (ISH). In this review, we highlight the differences between homeostatic hematopoiesis, which occurs in the bone marrow, and ISH, which occurs at mucosal surfaces. Further, we highlight factors produced at local sites of inflammation that regulate hematopoietic progenitor cell responses and the development of TH2 cytokine-mediated inflammation. Finally, we discuss the therapeutic potential of targeting ISH in preventing the development of inflammation at mucosal sites.

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References

Schnare M, BARTON G, Holt A, Takeda K, Akira S, Medzhitov R . Toll-like receptors control activation of adaptive immune responses. Nat Immunol. 2001; 2(10):947-50. DOI: 10.1038/ni712. View

Hui C, Rusta-Sallehy S, Asher I, Heroux D, Denburg J . The effects of thymic stromal lymphopoietin and IL-3 on human eosinophil-basophil lineage commitment: Relevance to atopic sensitization. Immun Inflamm Dis. 2014; 2(1):44-55. PMC: 4220668. DOI: 10.1002/iid3.20. View

Massberg S, Schaerli P, Knezevic-Maramica I, Kollnberger M, Tubo N, Moseman E . Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007; 131(5):994-1008. PMC: 2330270. DOI: 10.1016/j.cell.2007.09.047. View

Gauvreau G, OByrne P, Boulet L, Wang Y, Cockcroft D, Bigler J . Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014; 370(22):2102-10. DOI: 10.1056/NEJMoa1402895. View

Neilsen P, Cheney K, Li C, Chen J, Cawrse J, Schulz R . Identification of ANKRD11 as a p53 coactivator. J Cell Sci. 2008; 121(Pt 21):3541-52. DOI: 10.1242/jcs.026351. View

Wright D, Wagers A, Gulati A, Johnson F, Weissman I . Physiological migration of hematopoietic stem and progenitor cells. Science. 2001; 294(5548):1933-6. DOI: 10.1126/science.1064081. View

Allakhverdi Z, Comeau M, Armant M, Agrawal R, Woodfolk J, Sehmi R . Mast Cell-Activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34(+) Progenitor Cells. Front Immunol. 2014; 4:461. PMC: 3865761. DOI: 10.3389/fimmu.2013.00461. View

Hurst S, Muchamuel T, Gorman D, Gilbert J, Clifford T, Kwan S . New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002; 169(1):443-53. DOI: 10.4049/jimmunol.169.1.443. View

Wood L, Sehmi R, Gauvreau G, Watson R, Foley R, Denburg J . An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects. Am J Respir Crit Care Med. 1999; 159(5 Pt 1):1457-63. DOI: 10.1164/ajrccm.159.5.9808123. View

10.

Nussbaum J, Van Dyken S, von Moltke J, Cheng L, Mohapatra A, Molofsky A . Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013; 502(7470):245-8. PMC: 3795960. DOI: 10.1038/nature12526. View

11.

Le H, Kim W, Kim J, Cho H, Kwon B . Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies. Front Immunol. 2013; 4:104. PMC: 3644799. DOI: 10.3389/fimmu.2013.00104. View

12.

Saito H, Matsumoto K, Denburg A, Crawford L, Ellis R, Inman M . Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. J Immunol. 2002; 168(6):3017-23. DOI: 10.4049/jimmunol.168.6.3017. View

13.

Sehmi R, Howie K, Sutherland D, Schragge W, OByrne P, Denburg J . Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects. Am J Respir Cell Mol Biol. 1996; 15(5):645-55. DOI: 10.1165/ajrcmb.15.5.8918371. View

14.

Csaszar E, Kirouac D, Yu M, Wang W, Qiao W, Cooke M . Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell. 2012; 10(2):218-29. DOI: 10.1016/j.stem.2012.01.003. View

15.

Glatman Zaretsky A, Engiles J, Hunter C . Infection-induced changes in hematopoiesis. J Immunol. 2013; 192(1):27-33. PMC: 3874119. DOI: 10.4049/jimmunol.1302061. View

16.

Brusselle G, Maes T, Bracke K . Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med. 2013; 19(8):977-9. DOI: 10.1038/nm.3300. View

17.

Southam D, Widmer N, Ellis R, Hirota J, Inman M, Sehmi R . Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice. J Allergy Clin Immunol. 2005; 115(1):95-102. DOI: 10.1016/j.jaci.2004.09.022. View

18.

Kuo H, Wang C, Lin H, Hwang K, Liu S, Chung K . Interleukin-5 in growth and differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids. Br J Pharmacol. 2001; 134(7):1539-47. PMC: 1573080. DOI: 10.1038/sj.bjp.0704389. View

19.

Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S . Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int Immunol. 2002; 14(7):695-700. DOI: 10.1093/intimm/dxf039. View

20.

Saenz S, Taylor B, Artis D . Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol Rev. 2009; 226:172-90. PMC: 2683382. DOI: 10.1111/j.1600-065X.2008.00713.x. View