Infection-induced Changes in Hematopoiesis

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2013 Dec 24

PMID 24363432

Citations 51

Authors

Arielle Glatman Zaretsky

Julie B Engiles

Christopher A Hunter

Affiliations

Soon will be listed here.

Abstract

The bone marrow (BM) is an important site for the interrelated processes of hematopoiesis, granulopoiesis, erythropoiesis, and lymphopoiesis. A wide variety of microbial challenges are associated with profound changes in this compartment that impact on hematopoietic differentiation and mobilization of a variety of cell types. This article reviews some of the key pathways that control BM homeostasis, the infectious and inflammatory processes that affect the BM, and how addressing the knowledge gaps in this area has the potential to widen our comprehension of immune homeostasis.

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