TGF-β Signal Transduction Pathways and Osteoarthritis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2015 Mar 17

PMID 25773660

Citations 38

Authors

Guangju Zhai

Jules Dore

Proton Rahman

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.

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