Synovial Mast Cells and Osteoarthritis: Current Understandings and Future Perspectives

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Dec 25

PMID 39720069

Authors

Guanghui Hao

Shanqian Han

Zhangang Xiao

Jing Shen

Yueshui Zhao

Qi Hao

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a prevalent joint disease worldwide that significantly impacts the quality of life of individuals, particularly those in middle-aged and elderly populations. OA was initially considered as non-inflammatory arthritis, but recent studies have identified a substantial number of immune responses in OA, leading to the recognition of inflammation as a key factor in its pathogenesis. An increasing number of studies have found that mast cell (MC) and MC-secreted inflammatory mediators and cytokines are notably increased in the synovial fluid of OA patients, indicating a potential association between MCs and the onset and progression of synovial inflammation. The present review aims to summarize the significance and mechanism of MCs in the pathogenesis of OA. Meanwhile, we also discuss the clinical potential of using MCs as therapeutic target for OA therapy. Modulating the activities of MCs or the mediators of MCs in the synovial fluid inflammatory microenvironment will be promising new options for the treatment of OA.

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References

Xiao J, Zhang P, Cai F, Luo C, Pu T, Pan X . IL-17 in osteoarthritis: A narrative review. Open Life Sci. 2023; 18(1):20220747. PMC: 10579884. DOI: 10.1515/biol-2022-0747. View

Zhang H, Cai D, Bai X . Macrophages regulate the progression of osteoarthritis. Osteoarthritis Cartilage. 2020; 28(5):555-561. DOI: 10.1016/j.joca.2020.01.007. View

Ashraf S, Mapp P, Burston J, Bennett A, Chapman V, Walsh D . Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis. Ann Rheum Dis. 2013; 73(9):1710-8. PMC: 4145450. DOI: 10.1136/annrheumdis-2013-203416. View

Haywood L, McWilliams D, Pearson C, Gill S, Ganesan A, Wilson D . Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum. 2003; 48(8):2173-7. DOI: 10.1002/art.11094. View

Biosse-Duplan M, Baroukh B, Dy M, de Vernejoul M, Saffar J . Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol. 2009; 174(4):1426-34. PMC: 2671373. DOI: 10.2353/ajpath.2009.080871. View

Leist M, Sunder C, Drube S, Zimmermann C, Geldmacher A, Metz M . Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation. Exp Dermatol. 2016; 26(3):255-262. DOI: 10.1111/exd.13206. View

Ji Z, Li J, Tao S, Li H, Kong X, Huang B . Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches. Exp Mol Med. 2024; 56(5):1178-1192. PMC: 11148035. DOI: 10.1038/s12276-024-01230-1. View

Li Y, Luo W, Zhu S, Lei G . T Cells in Osteoarthritis: Alterations and Beyond. Front Immunol. 2017; 8:356. PMC: 5371609. DOI: 10.3389/fimmu.2017.00356. View

Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M . Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed. Arthritis Rheumatol. 2014; 67(4):903-13. DOI: 10.1002/art.38996. View

10.

Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24(2):179-89. DOI: 10.1016/j.immuni.2006.01.001. View

11.

Farah H, Wijesinghe S, Nicholson T, Alnajjar F, Certo M, Alghamdi A . Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses. Int J Mol Sci. 2022; 23(6). PMC: 8950319. DOI: 10.3390/ijms23063266. View

12.

McNeil H, Gotis-Graham I . Human mast cell subsets--distinct functions in inflammation?. Inflamm Res. 2000; 49(1):3-7. DOI: 10.1007/PL00012386. View

13.

Bulfone-Paus S, Bahri R . Mast Cells as Regulators of T Cell Responses. Front Immunol. 2015; 6:394. PMC: 4528181. DOI: 10.3389/fimmu.2015.00394. View

14.

Takano S, Uchida K, Inoue G, Matsumoto T, Aikawa J, Iwase D . Vascular endothelial growth factor expression and their action in the synovial membranes of patients with painful knee osteoarthritis. BMC Musculoskelet Disord. 2018; 19(1):204. PMC: 6020436. DOI: 10.1186/s12891-018-2127-2. View

15.

de Lange-Brokaar B, Kloppenburg M, Andersen S, Dorjee A, Yusuf E, Herb-van Toorn L . Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters. Osteoarthritis Cartilage. 2015; 24(4):664-71. DOI: 10.1016/j.joca.2015.11.011. View

16.

Kawai T, Akira S . Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007; 13(11):460-9. DOI: 10.1016/j.molmed.2007.09.002. View

17.

Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K . Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis. Clin Rheumatol. 2007; 26(8):1284-92. DOI: 10.1007/s10067-006-0495-8. View

18.

Abramoff B, Caldera F . Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Med Clin North Am. 2020; 104(2):293-311. DOI: 10.1016/j.mcna.2019.10.007. View

19.

Qiao H, Andrade M, Lisboa F, Morgan K, Beaven M . FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood. 2005; 107(2):610-8. PMC: 1895616. DOI: 10.1182/blood-2005-06-2271. View

20.

Seifert J, Kuchler C, Drube S . ATP/IL-33-Co-Sensing by Mast Cells (MCs) Requires Activated c-Kit to Ensure Effective Cytokine Responses. Cells. 2023; 12(23). PMC: 10705958. DOI: 10.3390/cells12232696. View