A Simplified Spin and Gradient Echo Approach for Brain Tumor Perfusion Imaging

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2015 Mar 11

PMID 25753958

Citations 16

Authors

Ashley M Stokes

C Chad Quarles

Affiliations

Soon will be listed here.

Abstract

Purpose: In this study, we propose a simplified acquisition and analysis approach for spin and gradient echo (SAGE)-based dynamic susceptibility-contrast MRI (DSC-MRI) data that is free of contrast agent T1 leakage effects.

Methods: A five-echo SAGE sequence was used to acquire DSC-MRI data in rat C6 tumors (n = 7). Nonlinear fitting of all echoes was performed to obtain T1-insensitive ΔR2* and ΔR2 time series. The simplified approach, which includes two gradient echoes and one spin echo, was also used to analytically compute T1-insensitive ΔR2* using the two gradient echoes and ΔR2 using all three echoes. The blood flow, blood volume, and vessel size values derived from each method were compared.

Results: In all cases, the five-echo and simplified SAGE ΔR2* and ΔR2 were in excellent agreement and demonstrated significant T1 leakage correction compared with the uncorrected single-echo data. The derived hemodynamic parameters for blood volume, blood flow, and vessel size were not significantly different between the two methods.

Conclusions: The proposed simplified SAGE technique enables the acquisition of gradient and spin echo DSC-MRI data corrected for T1 leakage effects yields parameters that are in agreement with the five-echo SAGE approach and does not require nonlinear fitting to extract ΔR2* and ΔR2 time series.

Citing Articles

Optimization and validation of multi-echo, multi-contrast SAGE acquisition in fMRI.

Keeling E, Bergamino M, Ragunathan S, Quarles C, Newton A, Stokes A Imaging Neurosci (Camb). 2024; 2:1-20.

PMID: 39449748 PMC: 11497078. DOI: 10.1162/imag_a_00217.

Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI.

Keeling E, Sisco N, McElvogue M, Borazanci A, Dortch R, Stokes A Magn Reson Imaging. 2024; 112:116-127.

PMID: 38971264 PMC: 11323764. DOI: 10.1016/j.mri.2024.07.007.

Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease.

Lee H, Fu J, Gaudet K, Bryant A, Price J, Bennett R J Cereb Blood Flow Metab. 2023; 44(5):787-800.

PMID: 38000018 PMC: 11197134. DOI: 10.1177/0271678X231216144.

Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual-spin-echo perfusion MRI.

Cao D, Sun Y, Li Y, Su P, Pillai J, Qiao Y NMR Biomed. 2023; 36(10):e4984.

PMID: 37308297 PMC: 10808973. DOI: 10.1002/nbm.4984.

High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques.

Henriksen O, Alvarez-Torres M, Figueiredo P, Hangel G, Keil V, Nechifor R Front Oncol. 2022; 12:810263.

PMID: 35359414 PMC: 8961422. DOI: 10.3389/fonc.2022.810263.

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