Lineage-specific Evolution of Methylthioalkylmalate Synthases (MAMs) Involved in Glucosinolates Biosynthesis

Overview

Journal Front Plant Sci

Date 2015 Feb 19

PMID 25691886

Citations 6

Authors

Jifang Zhang

Xiaobo Wang

Feng Cheng

Jian Wu

Jianli Liang

Wencai Yang

Xiaowu Wang

Affiliations

Soon will be listed here.

Abstract

Methylthioalkylmalate synthases (MAMs) encoded by MAM genes are central to the diversification of the glucosinolates, which are important secondary metabolites in Brassicaceae species. However, the evolutionary pathway of MAM genes is poorly understood. We analyzed the phylogenetic and synteny relationships of MAM genes from 13 sequenced Brassicaceae species. Based on these analyses, we propose that the syntenic loci of MAM genes, which underwent frequent tandem duplications, divided into two independent lineage-specific evolution routes and were driven by positive selection after the divergence from Aethionema arabicum. In the lineage I species Capsella rubella, Camelina sativa, Arabidopsis lyrata, and A. thaliana, the MAM loci evolved three tandem genes encoding enzymes responsible for the biosynthesis of aliphatic glucosinolates with different carbon chain-lengths. In lineage II species, the MAM loci encode enzymes responsible for the biosynthesis of short-chain aliphatic glucosinolates. Our proposed model of the evolutionary pathway of MAM genes will be useful for understanding the specific function of these genes in Brassicaceae species.

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