Gamma Oscillations and Their Cross-frequency Coupling in the Primate Hippocampus During Sleep

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2015 Feb 12

PMID 25669188

Citations 16

Authors

Saori Takeuchi

Tatsuya Mima

Rie Murai

Hideki Shimazu

Yoshikazu Isomura

Toru Tsujimoto

Affiliations

Soon will be listed here.

Abstract

Study Objectives: The mechanism by which sleep consolidates memory is unclear. Based on the two-stage model of memory consolidation, different functions for slow wave sleep (SWS) and rapid eye movement (REM) sleep have been proposed; thus, state-dependent changes of neural oscillations in the hippocampus might clarify this fundamental question.

Methods: We recorded hippocampal local field potentials from freely behaving monkeys via telemetry and analyzed their nonstationary oscillations using Hilbert-Huang transform.

Results: By applying a recently developed empirical mode decomposition analysis, we found strong cross-frequency coupling between high-frequency and slow wave oscillations during SWS and a prominent increase of gamma band activity in short bursts during REM sleep in unanesthetized primates' hippocampus.

Conclusion: Spatiotemporal integration through coupled oscillations during slow wave sleep might be a physiological basis of system consolidation, whereas gamma bursts during rapid eye movement sleep might be related to synaptic consolidation in the local hippocampal neural circuit.

Citing Articles

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Abbaspoor S, Hussin A, Hoffman K Elife. 2023; 12.

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