Self-reported Eating Speed in Relation to Non-alcoholic Fatty Liver Disease in Adults

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2015 Feb 5

PMID 25648740

Citations 17

Authors

Saehyun Lee

Byung-Joon Ko

Younghoon Gong

Kyungdo Han

Anna Lee

Byoung-Duck Han

Yeo Joon Yoon

Siyoung Park

Jung-Hyun Kim

Christos S Mantzoros

Affiliations

Soon will be listed here.

Abstract

Purpose: Non-alcoholic fatty liver disease (NAFLD), known to be related to insulin resistance, has been the focus of intensive research efforts due to its increasing prevalence and clinical significance. Rapid eating behavior is another emerging health issue associated with insulin resistance. We aimed to clarify the correlation between self-reported eating speed and NAFLD, both known to be related to insulin resistance.

Methods: A cross-sectional study was conducted during routine medical checkups on 7,917 consecutively enrolled participants. Anthropometric, biochemical, nutritional, and social parameters were checked. The self-reported eating speed per their usual meal (<5, 5-10, 10-15, and more than 15 min) was recorded by a registered dietitian.

Results: The faster eating groups had a higher proportion of NAFLD, and the grade of NAFLD was advanced. After controlling for anthropometric, cardiometabolic, social, and nutritional parameters, the fastest eating group (<5 min) showed an increased risk of NAFLD compared with the lowest eating speed group (≥15 min) both in total [odds ratio (OR) 1.81, 95% confidence interval (CI) 1.24-2.63] and the participants with BMI < 25 kg/m(2) (OR 1.79, 95% CI 1.22-2.61). As the self-reported eating speed increased, the risk of NAFLD also increased in total and those with BMI < 25 kg/m(2) (P for trend <0.001).

Conclusions: Fast eating is associated with an increased risk of the presence and grade of NAFLD in Korean adults, especially those with BMI < 25 kg/m(2), since presence of overweight or obesity may be overwhelming the effect on NAFLD.

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References

Targher G, Day C, Bonora E . Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010; 363(14):1341-50. DOI: 10.1056/NEJMra0912063. View

Fernandez-Garcia J, Murri M, Coin-Araguez L, Alcaide J, El Bekay R, Tinahones F . GLP-1 and peptide YY secretory response after fat load is impaired by insulin resistance, impaired fasting glucose and type 2 diabetes in morbidly obese subjects. Clin Endocrinol (Oxf). 2013; 80(5):671-6. DOI: 10.1111/cen.12221. View

Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G . A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010; 53(2):372-84. DOI: 10.1016/j.jhep.2010.04.008. View

Karl J, Young A, Rood J, Montain S . Independent and combined effects of eating rate and energy density on energy intake, appetite, and gut hormones. Obesity (Silver Spring). 2013; 21(3):E244-52. DOI: 10.1002/oby.20075. View

Younossi Z, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H . Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol. 2011; 9(6):524-530.e1. DOI: 10.1016/j.cgh.2011.03.020. View

Tsatsoulis A, Mantzaris M, Bellou S, Andrikoula M . Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective. Metabolism. 2012; 62(5):622-33. DOI: 10.1016/j.metabol.2012.11.004. View

Kral J, Buckley M, Kissileff H, Schaffner F . Metabolic correlates of eating behavior in severe obesity. Int J Obes Relat Metab Disord. 2001; 25(2):258-64. DOI: 10.1038/sj.ijo.0801469. View

Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K . Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. J Epidemiol. 2006; 16(3):117-24. PMC: 7603906. DOI: 10.2188/jea.16.117. View

Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa S . Self-reported speed of eating and 7-year risk of type 2 diabetes mellitus in middle-aged Japanese men. Metabolism. 2012; 61(11):1566-71. DOI: 10.1016/j.metabol.2012.04.005. View

10.

Svegliati-Baroni G, Saccomanno S, Rychlicki C, Agostinelli L, De Minicis S, Candelaresi C . Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011; 31(9):1285-97. DOI: 10.1111/j.1478-3231.2011.02462.x. View

11.

Lalic N, Paulweber M, Stadlmayr A, Kedenko L, Djordevic P, Abraham C . A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res. 2010; 42 Suppl 1:S3-36. DOI: 10.1055/s-0029-1240928. View

12.

Smith B, Adams L . Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat Rev Endocrinol. 2011; 7(8):456-65. DOI: 10.1038/nrendo.2011.72. View

13.

Maruyama K, Sato S, Ohira T, Maeda K, Noda H, Kubota Y . The joint impact on being overweight of self reported behaviours of eating quickly and eating until full: cross sectional survey. BMJ. 2008; 337:a2002. PMC: 2572205. DOI: 10.1136/bmj.a2002. View

14.

Gaggini M, Morelli M, Buzzigoli E, DeFronzo R, Bugianesi E, Gastaldelli A . Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients. 2013; 5(5):1544-60. PMC: 3708335. DOI: 10.3390/nu5051544. View

15.

Machado M, Marques-Vidal P, Cortez-Pinto H . Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol. 2006; 45(4):600-6. DOI: 10.1016/j.jhep.2006.06.013. View

16.

Michalakis K, Mintziori G, Kaprara A, Tarlatzis B, Goulis D . The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism. 2012; 62(4):457-78. DOI: 10.1016/j.metabol.2012.08.012. View

17.

Tanihara S, Imatoh T, Miyazaki M, Babazono A, Momose Y, Baba M . Retrospective longitudinal study on the relationship between 8-year weight change and current eating speed. Appetite. 2011; 57(1):179-83. DOI: 10.1016/j.appet.2011.04.017. View

18.

Karagozian R, Derdak Z, Baffy G . Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism. 2014; 63(5):607-17. DOI: 10.1016/j.metabol.2014.01.011. View

19.

Schwarz P, Greaves C, Lindstrom J, Yates T, Davies M . Nonpharmacological interventions for the prevention of type 2 diabetes mellitus. Nat Rev Endocrinol. 2012; 8(6):363-73. DOI: 10.1038/nrendo.2011.232. View

20.

Saadeh S, Younossi Z, Remer E, Gramlich T, Ong J, Hurley M . The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002; 123(3):745-50. DOI: 10.1053/gast.2002.35354. View