Neuroinflammation and Neuroimmune Dysregulation After Acute Hypoxic-ischemic Injury of Developing Brain

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2015 Feb 3

PMID 25642419

Citations 66

Authors

Utpal S Bhalala

Raymond C Koehler

Sujatha Kannan

Affiliations

Soon will be listed here.

Abstract

Hypoxic-ischemic (HI) injury to developing brain results from birth asphyxia in neonates and from cardiac arrest in infants and children. It is associated with varying degrees of neurologic sequelae, depending upon the severity and length of HI. Global HI triggers a series of cellular and biochemical pathways that lead to neuronal injury. One of the key cellular pathways of neuronal injury is inflammation. The inflammatory cascade comprises activation and migration of microglia - the so-called "brain macrophages," infiltration of peripheral macrophages into the brain, and release of cytotoxic and proinflammatory cytokines. In this article, we review the inflammatory and immune mechanisms of secondary neuronal injury after global HI injury to developing brain. Specifically, we highlight the current literature on microglial activation in relation to neuronal injury, proinflammatory and anti-inflammatory/restorative pathways, the role of peripheral immune cells, and the potential use of immunomodulators as neuroprotective compounds.

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