Role of Maternal Immune Factors in Neuroimmunology of Brain Development

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2023 Dec 6

PMID 38057641

Authors

Mehdi Mohebalizadeh

Golsa Babapour

Mahdi Maleki Aghdam

Tooba Mohammadi

Reza Jafari

Vahid Shafiei-Irannejad

Affiliations

Soon will be listed here.

Abstract

Inflammation during pregnancy may occur due to various factors. This condition, in which maternal immune system activation occurs, can affect fetal brain development and be related to neurodevelopmental diseases. MIA interacts with the fetus's brain development through maternal antibodies, cytokines, chemokines, and microglial cells. Antibodies are associated with the development of the nervous system by two mechanisms: direct binding to brain inflammatory factors and binding to brain antigens. Cytokines and chemokines have an active presence in inflammatory processes. Additionally, glial cells, defenders of the nervous system, play an essential role in synaptic modulation and neurogenesis. Maternal infections during pregnancy are the most critical factors related to MIA; however, several studies show the relation between these infections and neurodevelopmental diseases. Infection with specific viruses, such as Zika, cytomegalovirus, influenza A, and SARS-CoV-2, has revealed effects on neurodevelopment and the onset of diseases such as schizophrenia and autism. We review the relationship between maternal infections during pregnancy and their impact on neurodevelopmental processes.

Citing Articles

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PMID: 39544374 PMC: 11560794. DOI: 10.3389/fpsyt.2024.1465291.

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