Mouse Models of Breast Cancer

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2015 Feb 1

PMID 25636464

Citations 17

Authors

Kazuhito Sakamoto

Jeffrey W Schmidt

Kay-Uwe Wagner

Affiliations

Soon will be listed here.

Abstract

Breast cancer is the most common cause of cancer death in women worldwide. This malignancy is a complex disease, which is defined by an intrinsic heterogeneity on the histopathological and molecular level as well as response to therapy and outcome. In addition to classical histopathological features, breast cancer can be categorized into at least five major subtypes based on comprehensive gene expression profiling: luminal A, luminal B, basal-like, ERBB2-positive, and normal-like breast cancer. Genetically engineered mouse models can serve as tools to study the molecular underpinnings for this disease. Given the genetic complexity that drives the initiation and progression of individual breast cancer subtypes, it is evident that certain models can reflect only particular aspects of this malignancy. In this book chapter, we will primarily focus on advances in modeling breast cancer at defined stages of carcinogenesis using genetically engineered mice. We will discuss the ability as well as shortcomings of these models to faithfully recapitulate the spectrum of human breast cancer subtypes.

Citing Articles

Mammary Cancer Models: An Overview from the Past to the Future.

Silva J, Oliveira P, Duarte J, Faustino-Rocha A In Vivo. 2024; 39(1):1-16.

PMID: 39740866 PMC: 11705154. DOI: 10.21873/invivo.13800.

Mechanism of isoflurane‑mediated breast cancer growth .

Koutsogiannaki S, Wang W, Hou L, Okuno T, Yuki K Oncol Lett. 2024; 27(6):287.

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Isolating Primary Tumor Cells from the MMTV-PyMT Mouse Model and Their Use in Developing an Orthotopic Mouse Model of Breast Cancer.

Kozak A, Vasiljeva O, Mikhaylov G Methods Mol Biol. 2024; 2773:59-65.

PMID: 38236536 DOI: 10.1007/978-1-0716-3714-2_6.

Cellular Plasticity in Mammary Gland Development and Breast Cancer.

Wicker M, Wagner K Cancers (Basel). 2023; 15(23).

PMID: 38067308 PMC: 10705338. DOI: 10.3390/cancers15235605.

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity.

Broeker C, Ortiz M, Murillo M, Andrechek E Breast Cancer Res. 2023; 25(1):120.

PMID: 37805590 PMC: 10559619. DOI: 10.1186/s13058-023-01723-3.

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